Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Goldenseal root powder M980070

 

CASRN: GOLDENSEALRT

Synonyms/Common Names

  • Powdered root of goldenseal

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C99007)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1560, 3121, 6250, 12500, 25000 OR 50000 PPM; 5/SEX/SPECIES.
  • 13 weeks (Dosed-Feed)  (C99007B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/SEX/SPECIES.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C99007B)  Completed 
    • TR-562 (NIH Number: 10-5903)  (Peer Review Approval 02/25/2009A )
      Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 3000, 9000, OR 25, 000 PPM.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0856)  Completed 
    • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
    • Human (Cell Lines)
    • Dose: 0, 1, 10, 100 uM..

Genetic Toxicology

  • Micronucleus  (A21831)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A83314)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 6 to 20 GD Conventional Teratology (Dosed-Feed)  (TER98007)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 3125, 6250, 12, 500 OR 18, 400 PPM.
  • 6 to 17 GD Conventional Teratology (Dosed-Feed)  (TER99004)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 3125, 12, 500, OR 50, 000 PPM.
  • 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)  (TRP98007)  Completed 
    • Rats: Sprague Dawley
    • Dose: 0, 3125, 6250, 12, 500, 25, 000, OR 50, 000 PPM.
  • 6 to 17 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99007)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 3125, 6250, 12, 500, 25, 000 OR 50, 000 PPM.