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Testing Status of 2,2',4,4'-Tetrabromodiphenyl Ether M980090

 

CASRN: 5436-43-1

Formula: C12-H6-Br4-O

Synonyms/Common Names

  • BDE-47
  • Benzene,1,1'-oxybis(2,4-dibromo)-(9CI)
  • DE-47
  • Flame Retardant 2
  • PBDE 47

Short-Term Toxicity

  • PND 12 to 21 (Gavage)  (C20208)  Completed 
    • Mice: BALB/cByJ; Mice: CB6F1-Tg(HRAS)2Jic [(BALB/cByJTac x C57BL/6JTac)-Tg(HRAS)2Jic F1
    • Dose: FM: 0, 25, 50, 100, OR 200 mg/kg.
  • Special study (Gavage)  (C20208)  Completed 
    • Mice: CB6F1-Tg(HRAS)2Jic [(BALB/cByJTac x C57BL/6JTac)-Tg(HRAS)2Jic F1
  • 5 days (Gavage)  (C98090C)  Report in Preparation 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
  • GD 6 to PND 21 (Gavage)  (C98090B)  Completed 
    • In Utero-PND22 Exposure to BDE47
    • Rats: Wistar Han
    • Dose: 0, 0.1, 15, or 50 mg/kg; 10 dams/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0921)  Completed 
    • Citation: Sanders JM, Chen LJ, Lebetkin EH, Burka LT. Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica. 2006 Jan;36(1):103-17.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: From 0.1 to 1000 umol/kg.
  • C. elegans  (W98090)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans: N2
    • Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uM Feeding:0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uM.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G98090)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G98090B)  On Test 
    • Human (Cell Lines)
  • Salmonella  (A90466)  Completed 
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Gavage)  (T98090)  Completed 
    • In Utero - PND 22 Exposure to BDE-47
    • Rats: Wistar Han
  • 5 days Microarray Analysis (Gavage)  (T98090B)  Report in Preparation 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.