Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Androstenedione M990002

 

CASRN: 63-05-8

Formula: C19-H26-O2

Synonyms/Common Names

  • 4-Androstene-3,17-dione
  • Androtex

Short-Term Toxicity

  • 2 weeks (Gavage)  (C99024)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 5/SEX/SPECIES.
  • 2 weeks (Topical Application)  (C99024B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 5/SEX/SPECIES.
  • 13 weeks (Gavage)  (C99024C)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 10/SEX/SPECIES; 5X/WEEK.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C99024C)  Completed 
    • TR-560 (NIH Number: 10-5901)  (Peer Review Approval 02/25/2009A )
      Toxicology and Carcinogenesis Studies of Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: RATS & MALE MICE: 0, 10, 20, OR 50 MG/KG FEMALE MICE: 0, 2, 10, OR 50 MG/KG; 50/SEX/SPECIES.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; in-vitro)  (S0812)  Completed 
    • Male and Female Rats; Male and Female Mice; Male and Female Human (Cell Lines)
  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; in-vitro; Gavage; in-vitro; Gavage; Intravenous; in-vitro)  (S0840)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Dogs: Beagles; Male and Female Human (Cell Lines)
    • Dose: 1, 10, 100 mg/kg. 1, 10, 100 mg/kg [R,M]. 1, 100 mg/kg. 1.1 mg/kg. 10 or 100 uM [R, M, HU].

Genetic Toxicology

  • Micronucleus  (A71952)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Micronucleus  (A80598)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A21570)  Completed 
    •  Negative 
  • Salmonella  (A53831)  Completed 
    •  Negative