Testing Status of Androstenedione M990002
CASRN: 63-05-8
Formula: C19-H26-O2
Synonyms/Common Names
- 4-Androstene-3,17-dione
- Androtex
Short-Term Toxicity
- 2 weeks (Gavage)
(C99024)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 5/SEX/SPECIES.
- 2 weeks (Topical Application)
(C99024B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 5/SEX/SPECIES.
- 13 weeks (Gavage)
(C99024C)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 1, 5, 10, 20, OR 50 MG/KG; 10/SEX/SPECIES; 5X/WEEK.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C99024C)
Completed
- TR-560 (NIH Number: 10-5901)
(Peer Review Approval 02/25/2009A )
Toxicology and Carcinogenesis Studies of Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Equivocal Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: RATS & MALE MICE: 0, 10, 20, OR 50 MG/KG FEMALE MICE: 0, 2, 10, OR 50 MG/KG; 50/SEX/SPECIES.
- TR-560 (NIH Number: 10-5901)
(Peer Review Approval 02/25/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; in-vitro)
(S0812)
Completed
- Male and Female Rats; Male and Female Mice; Male and Female Human (Cell Lines)
- Absorption Disposition Metabolism Elimination (in-vitro; Gavage; Intravenous; in-vitro)
(S0840)
Completed
- Male and Female Rats: F344/N; Male Mice: B6C3F1; Male and Female Dogs: Beagles; Human (Cell Lines)
- Dose: In vivo experiments: Beagle dogs were administered 14C-androstenedione by intravenous (10 mg/kg) and by oral administration (100 mg/kg). In vitro metabolite profiles: In vitro experiments have been performed with androstenedione at 10 and 100 µM incubated using Fischer 344 rat, B6C3F1 mouse, and human hepatocytes..
Genetic Toxicology
- Micronucleus
(A71952)
Completed
- Mice: B6C3F1
- Male Negative
- Female Equivocal
- Micronucleus
(A80598)
Completed
- Rats: Fischer 344
- Male Negative
- Salmonella
(A21570)
Completed
- Negative
- Salmonella
(A53831)
Completed
- Negative