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Testing Status of alpha/beta Thujone mixture M990011

 

CASRN: 76231-76-0

Formula: C10-H16-O

Synonyms/Common Names

  • Mixture of alpha & beta Thujone

Secondary:

  • 546-80-5 - alpha-Thujone
  • 471-15-8 - beta-Thujone

Short-Term Toxicity

  • 5 days (Gavage)  (C99011)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 1.5, 3, 6.25, 12.5, 25, 50, 100, or 200 mg/kg; N=4.
  • 2 weeks (Gavage)  (C99037)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: 0, 1, 3, 10, 30, OR 100 MG/KG/DAY.
  • 13 weeks (Gavage)  (C99037B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 12.5, 25, 50, 75, OR 100 MG/KG M: 0, 6.25, 12.5, 25, 50, OR 75 MG/KG; 10/SEX/SPECIES, 5X/WEEK.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C99037B)  Completed 
    • TR-570 (NIH Number: 11-5912)  (Peer Review Approval 01/26/2011A )
      Toxicology and Carcinogenesis Studies of α,β-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 12.5, 25, OR 50 MG/KG M: 0, 3, 6, 12, OR 25 MG/KG 50/SEX/SPECIES.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (K06898)  Completed 
    • Citation: Waidyanatha S, Johnson JD, Hong SP, Robinson VG, Gibbs S, Graves SW, Hooth MJ, Smith CS. Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice. Toxicol Appl Pharmacol. 2013 Sep 271(2):216-28. doi: 10.1016/j.taap.2013.05.001. Epub 2013 May 10.Pubmed Abstract
    • Rats: Fischer 344; Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A26162)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (A36495)  Completed 
    •  Negative 

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T99011)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley