Testing Status of Milk thistle extract M990059
CASRN: 84604-20-6
Synonyms/Common Names
- Lady's thistle extract
- Silybum marianum extract
Short-Term Toxicity
- 5 days (Gavage)
(C99059)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Male rats: 0, 39.1, 78.125, 156.25, 312.5, 625, 937.5, 1250, or 1750 mg/kg; N=4.
- 13 weeks (Dosed-Feed)
(C20008)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/SEX/SPECIES.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C20008)
Completed
- TR-565 (NIH Number: 10-5907)
(Peer Review Approval 11/19/2009A )
Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 12500, 25000, OR 50000 PPM; 50/SEX/SPECIES.
- TR-565 (NIH Number: 10-5907)
(Peer Review Approval 11/19/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (in-vitro)
(S0857)
Completed
- Human (Cell Lines)
- Dose: 0, 1, 10, 100 uM..
Genetic Toxicology
- Micronucleus
(A73501)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(A21904)
Completed
- Positive
- Salmonella
(A41673)
Completed
- Negative
- Salmonella
(A42260)
Completed
- Negative
- Salmonella
(A44499)
Completed
- Negative
- Salmonella
(A78884)
Completed
- Positive
- Salmonella
(G99059)
Completed
- Positive
Toxicogenomics
- 5-day Transcriptome Sequencing (Gavage)
(T99059)
On Test
- Rats: Harlan Sprague-Dawley