Alimentary System

Salivary Gland - Inflammation

    Narrative
    Salivary gland - Inflammation, Acute in a male F344/N rat from a subchronic study. There is widespread destruction of the salivary tissue with abundant inflammatory cells.
    Salivary gland - Inflammation, Acute in a male F344/N rat from a subchronic study. There is widespread destruction of the salivary tissue with abundant inflammatory cells.
    Salivary gland - Inflammation, Acute in a male F344/N rat from a subchronic study (higher magnification of Figure 1). The inflammatory cells are mainly neutrophils, and there is necrosis of the glandular tissue (arrow).
    Salivary gland - Inflammation, Acute in a male F344/N rat from a subchronic study (higher magnification of Figure 1). The inflammatory cells are mainly neutrophils, and there is necrosis of the glandular tissue (arrow).
    Salivary gland - Inflammation, Suppurative in a female B6C3F1 mouse from a chronic study. There are areas of inflammation with necrosis surrounded by fibrosis (arrow), characteristic of an abscess.
    Salivary gland - Inflammation, Suppurative in a female B6C3F1 mouse from a chronic study. There are areas of inflammation with necrosis surrounded by fibrosis (arrow), characteristic of an abscess.
    Salivary gland - Inflammation, Suppurative in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 3). The inflammatory cells are mainly degenerate neutrophils surrounding large colonies of bacteria (arrow), which are surrounded by fibrosis.
    Salivary gland - Inflammation, Suppurative in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 3). The inflammatory cells are mainly degenerate neutrophils surrounding large colonies of bacteria (arrow), which are surrounded by fibrosis.
    Salivary gland - Inflammation, Granulomatous in a male B6C3F1 mouse from a chronic study. An entire lobe is replaced by granulomatous inflammation (arrows).
    Salivary gland - Inflammation, Granulomatous in a male B6C3F1 mouse from a chronic study. An entire lobe is replaced by granulomatous inflammation (arrows).
    Salivary gland - Inflammation, Granulomatous in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5). The inflammation is characterized by the presence of multinucleated giant cells (arrow) and numerous epithelioid macrophages (arrowhead).
    Salivary gland - Inflammation, Granulomatous in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5). The inflammation is characterized by the presence of multinucleated giant cells (arrow) and numerous epithelioid macrophages (arrowhead).

    Authors:

    Linda H. Kooistra, DVM, PhD, DACVP
    Pathologist
    Charles River Laboratories, Inc.
    Research Triangle Park, NC

    Abraham Nyska, DVM, Diplomate ECVP, Fellow IATP
    Expert in Toxicologic Pathology
    Visiting Full Professor of Pathology
    Sackler School of Medicine, Tel Aviv University Timrat Israel

    Reviewers:

    Joel R. Leininger, DVM, PhD
    Senior Pathologist
    MedImmune
    Washington, DC

    Amy Brix, DVM, PhD, DACVP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC