Respiratory System

Nose, Nerve - Atrophy

    Narrative
    Nose, Nerve - Atrophy in a female F344/N rat from a subchronic study. The olfactory nerves in the lamina propria are small and decreased in number (arrows), and there is loss of cells in the olfactory epithelium.
    Nose, Nerve - Atrophy in a female F344/N rat from a subchronic study. The olfactory nerves in the lamina propria are small and decreased in number (arrows), and there is loss of cells in the olfactory epithelium.
    Nose, Nerve - Atrophy in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The olfactory nerves in the lamina propria are decreased in size and number (arrows), and there is loss of cells in the olfactory epithelium.
    Nose, Nerve - Atrophy in a female F344/N rat from a subchronic study (higher magnification of Figure 1). The olfactory nerves in the lamina propria are decreased in size and number (arrows), and there is loss of cells in the olfactory epithelium.
    Nose, Nerve - Atrophy in a male B6C3F1/N mouse from a chronic study. No olfactory nerves remain in the lamina propria.
    Nose, Nerve - Atrophy in a male B6C3F1/N mouse from a chronic study. No olfactory nerves remain in the lamina propria.
    Nose, Nerve - Normal in a female B6C3F1/N mouse from a chronic study. Normal size and number of olfactory nerves are shown for comparison with Figure 3.
    Nose, Nerve - Normal in a female B6C3F1/N mouse from a chronic study. Normal size and number of olfactory nerves are shown for comparison with Figure 3.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC