Application of CATMoS to Predict Acute Mammalian Toxicity for Pesticide Hazard and Risk Assessment

CATMoS is a set of predictive in silico models of acute oral systemic toxicity potential. The consensus model predictions are fully reproducible and demonstrate equivalent performance to in vivo data. This offers an opportunity for a potential replacement to animal testing for applications such as regulatory evaluations of pesticide toxicity. EPA and NIEHS scientists are evaluating CATMoS predictions for 178 chemicals in comparison to rat LD50 tests from publicly available ecological risk assessments registered from 1998 to 2020. Findings from this study will help in understanding the applicability of CATMoS estimates as a potential replacement of the rat acute single oral dose study for establishing the effects endpoint in ecological risk assessments.