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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods
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Pred-Skin Web Portal for Predicting Human Skin Sensitizers

In collaboration with scientists at the University of North Carolina at Chapel Hill and the Universidade Federal de Goiás, NICEATM scientists contributed to the development of a model to predict skin sensitization potential of chemicals for two assays, the human patch test and murine local lymph node assay, and implemented this model in a web portal (Braga et al. 2017). Pred-Skin v. 3.0 (Borba et al. 2021) revised and expanded the freely accessible web tool to integrate multiple QSAR models developed with in vitro, animal in vivo, and human predictive patch test data into a consensus naïve Bayes model that predicts human effects.

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