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Testing Status of Azodicarbonamide 10086-W


CASRN: 123-77-3

Formula: C2-H4-N4-O2

Synonyms/Common Names

  • Diazenedicarboxamide

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55981C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55981C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 50, 100, OR 200 MG/M3.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0457)  Completed 
    • Citation: Gerlach RF, Medinsky MA, Hobbs CH, Bice DE, Bechtold WE, Cheng YS, Gillett NA, Birnbaum LS, Mauderly JL. Effect of four-week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non-specific airway sensitivity of the guinea pig. J Appl Toxicol. 1989 Jun;9(3):145-53.Pubmed Abstract
    • Citation: Shopp GM, Cheng YS, Gillett NA, Bechtold WE, Medinsky MA, Hobbs CH, Birnbaum LS, Mauderly JL. Acute inhalation exposure of azodicarbonamide in the guinea pig. Am Ind Hyg Assoc J. 1987 Feb;48(2):127-32.Pubmed Abstract
    • Guinea Pigs
  • Absorption Distribution Metabolism Excretion (Dosed-Feed)  (S0458)  Completed 
    • Male Rats: F344/N
    • Dose: 8 UCI, 48 hr study done at IRDC.
  • Toxicokinetic Study (Inhalation)  (S0058)  Completed 
    • Citation: Mewhinney JA, Ayres PH, Bechtold WE, Dutcher JS, Cheng YS, Bond JA, Medinsky MA, Henderson RF, Birnbaum LS. The fate of inhaled azodicarbonamide in rats. Fundam Appl Toxicol. 1987 Apr;8(3):372-81.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Drosophila  (831837)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (998177)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • Salmonella  (727470)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive