Nominate to NTP

The NTP testing program evaluates substances for a variety of health-related effects. Rodent models are generally used for study. For each substance studied, a study scientist designs a comprehensive testing strategy. The strategy addresses the identified research and testing needs to fully characterize its toxic potential. A project review committee evaluates the strategy.

Substances are studied for a variety of health-related effects, including but not limited to:

• Carcinogenicity
• Genotoxicity
• Immunotoxicity
• Metabolism and disposition
• Reproductive and developmental toxicity

The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) activities support the development and evaluation of new, revised, and alternative methods to identify potential hazards to human health and the environment. The activities focus on replacing, reducing, or refining animal use.

NICEATM administers nominations of test methods for the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM is a coordinating committee that evaluates the usefulness of test methods for a specific proposed regulatory requirement or application.

Health Assessment and Translation (HAT) group serves as an environmental health resource to the public and to regulatory and health agencies. HAT conducts technical assessments focused on understanding the potential for adverse effects on human health through substance exposure.

The Report on Carcinogens is a congressionally mandated, science-based, public health report prepared by NTP on behalf of the Secretary, Health and Human Services. The report contains a list of substances in our environment that pose a hazard to people residing in the United States.

The Predictive Toxicology Branch develops and carries out programs in medium- and high-throughput screening of environmental substances for rapid detection of biological activities of significance to toxicology. The Branch accepts nominations of high-throughput or high-content screens for possible use in NTP's high-throughput screening initiative, Tox21.