Submit a Nomination
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In its 40+-year history, the NTP partnership has evaluated more than 2800 substances, including occupational exposures, environmental pollutants, food additives, consumer products, and pharmaceuticals, for a variety of health-related effects, such as general toxicity, carcinogenicity, genotoxicity, and effects on reproduction and development and the immune, nervous, and cardiovascular systems.
NTP is interested to learn of chemicals, mixtures, or exposures circumstances, and toxicological issues that might merit research to fill important gaps in knowledge about toxicity and translate that knowledge into decision-making to improve public health. NTP follows specific guidance in determining whether to take-on a new initiative. Preference is given to requests where there are identified stakeholders, discrete knowledge gaps, and a visible path to achieving actionable outcomes.
NTP leadership evaluates these research requests following specific guidance and engages in deliberate decision-making before adding a new initiative to the NTP portfolio. The level of deliberation and review for a new initiative is flexible and appropriate to its objective, scope, intended outputs, anticipated resource needs, and public-health impact. Please note that NTP's consideration of a research request does not imply any federal commitment for action.
NTP Input Guidance
NTP follows specific guidance in determining whether to take on a new initiative*.
- Substances found at home, in the workplace, or in our environment that are not associated with a single commercial organization.
- Naturally occurring substances that may not be adequately evaluated without federal involvement.
- Commercial products with significant exposure that were first marketed prior to current testing requirements or those that generate too little revenue to support further evaluations.
- Potential substitutes for existing chemicals or drugs that might not be developed without federal involvement.
- Mixtures of substances, or combinations of exposures, or exposure circumstances, for which evaluations are not required under applicable legislative authorities.
- Substances that would aid in the understanding mechanisms of chemical toxicities.
- Substances that would aid in development of new methods or approaches to evaluate potential toxicities.
- Substances that should be evaluated to improve the scientific understanding of structure-activity relationships and thereby help limit the number of substances requiring extensive evaluations.
- Emergencies or other events that warrant immediate federal government evaluation of a substance.
- It is expected that the private sector will evaluate substances for health and environmental effects as required and mandated by Congress under applicable legislative authorities.
*Note: NTP does NOT do the following:
- Accept proposals for funding of extramural research by academic groups.
- "Test chemicals" on behalf of private sector entities.
- Biomonitoring or blood tests for individuals.