Testing Status of N-Nitroso-N-methylurea 11184-E
CASRN: 684-93-5
Formula: C2-H5-N3-O2
Synonyms/Common Names
- 1-Methyl-1-nitrosourea
Genetic Toxicology
- Micronucleus
(A35550)
Completed
- Mice: B6C3F1
- Male Positive
Organ Systems Toxicity
- Dominant Lethal (Male)
(DLM027)
Completed
- Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
- Male Mice: 101 X C3H
- Mice Male Positive
- Heritable Translocation Test
(HTM34)
Completed
- Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
- Male Mice: 101 X C3H
- Mice Male Positive
- Morphological Specific Locus
(MSLM45)
Completed
- Citation: Russell, W.L. and Hunsicker, P.R. Extreme sensitivity of one particular germ cell stage in male mice to induction of specific-locus mutations by methylnitrosourea. Environ. Mutagen. 5:498 (1983)
- Male Mice: 101 X C3H
- Mice Male Positive
- PYRAN 3 GD, MNU 9 GD Teratology Pilot Studies (Gavage & Intraperitoneal Injection)
(TRP92060)
Completed
- Male and Female Mice: Swiss & C57BL/6
- Dose: 10 MG/KG MNU (GD 9) + 10 MG/KG PYRAN.
- Total Reproductive Capacity (Intraperitoneal Injection)
(TRC98024)
Completed
- Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
- Female Mice
- Mice Female Positive