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Testing Status of Hexamethyl-p-rosaniline chloride 10008-R

 

CASRN: 548-62-9

Formula: C25-H30-N3.Cl

Synonyms/Common Names

  • Gentian violet
  • Gentian violet
  • Methanaminium, N-(4-(bis(4-(dimethylamino)phenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-methyl-, chloride

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C55969B)  Completed 
    • NR-304
      Chronic Toxicity and Carcinogenesis Studies of Gentian Violet in Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C55969)  Completed 
    • NR-338
      Chronic Toxicity and Carcinogenesis Study of Gentian Violet in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C55969B)  Completed 
    • NR-304  (Peer Review Approval NA)
      Chronic Toxicity and Carcinogenesis Studies of Gentian Violet in Mice (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Mice: B6C3F1
    • Dose: 0, 100, 300, 600 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C55969)  Completed 
    • NR-338  (Peer Review Approval NA)
      Chronic Toxicity and Carcinogenesis Study of Gentian Violet in Fischer 344 Rats (Contact CDM@niehs.nih.gov for an electronic copy of this report)
    • Rats: F344/N
    • Dose: 0, 100, 300, 600 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (126650)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (088988)  Completed 
    • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (724862)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Salmonella  (643487)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Equivocal 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER82079)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 2.5, 5, 10 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER82080)  Completed 
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: .5, 1, 2 MG/KG/DAY.