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Testing Status of Pyrilamine 10198-S

 

CASRN: 91-84-9

Formula: C17-H23-N3-O

Synonyms/Common Names

  • N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60651)  Completed 
    • NR-408/409  (Peer Review Approval NA)
      Pyrilamine: 104 Week Chronic Dose Study in Rats and Pyrilamine: 104 Week Chronic Dose Study in Mice (Contact ntpwebrequest@niehs.nih.gov for an electronic copy of this report).
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60651)  Completed 
    • NR-408/409
      Pyrilamine: 104 Week Chronic Dose Study in Rats and Pyrilamine: 104 Week Chronic Dose Study in Mice (Contact ntpwebrequest@niehs.nih.gov for an electronic copy of this report).
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60651)  Completed 
    • NR-408/409  (Peer Review Approval NA)
      Pyrilamine: 104 Week Chronic Dose Study in Rats and Pyrilamine: 104 Week Chronic Dose Study in Mice (Contact ntpwebrequest@niehs.nih.gov for an electronic copy of this report).
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 300, 1500, 3000, M: 0, 150, 750, 1500 PPM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (304876)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (955830)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative