Testing Status of Bleomycin M88086

CASRN: 11056-06-7

Formula: C55-H84-N20-O21-S2.C55-H84-N17-O21-S3

Synonyms/Common Names

• Bleomycin

Organ Systems Toxicity

• Dominant Lethal (Female) (Inhalation)  (DLF013)  Completed 
  • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
  • Female Mice: SEC X C57BL
  • Mice Female Positive 
• Dominant Lethal (Female) (Dosed-Water)  (DLF014)  Completed 
  • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
  • Female Mice: C3H X C57BL
  • Mice Female Positive 
• Dominant Lethal (Male) (Dosed-Feed)  (DLM012)  Completed 
  • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
  • Male Mice: 101 X C3H
  • Mice Male Negative 
• Morphological Specific Locus (Dosed-Feed)  (MSLT96002)  Completed 
  • Citation: Russell, LB, Hunsicker, PR, and Shelby, MD. Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice. Mutation Res. 358: 25-35 (1996).
  • Female Mice: C3H X 101
  • Mice Female Positive 
• Total Reproductive Capacity (Gavage)  (TRC98045)  Completed 
  • Citation: Sudman, P.D. and Generoso, W.M. Female-specific mutagenic response of mice to hycanthone. Mutation Res. 246: 31-43 (1991).
  • Female Mice
  • Mice Female Positive