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Testing Status of Berberine chloride dihydrate M990031

 

CASRN: 5956-60-5

Formula: C20-H18-N-O4.Cl.2H2-O

Synonyms/Common Names

  • Berberine hydrochloride bihydrate
  • 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride dihydrate

Organ Systems Toxicity

  • 6 to 20 GD Conventional Teratology (Gavage)  (TER20102)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 1000 MG/KG.
  • 6 to 17 GD Conventional Teratology (Gavage)  (TER20103)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 1000 MG/KG.
  • 6 to 20 GD Conventional Teratology (Dosed-Feed)  (TER98008)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 3625, 7250, OR 14, 500 PPM.
  • 6 to 17 GD Conventional Teratology (Dosed-Feed)  (TER99002)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 3500, 5250, OR 7000 PPM.
  • 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)  (TRP98008)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 200, 400, 800, 1200, OR 1600 PPM IN FEED.
  • 6 to 17 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99003)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 80, 160, 320, 480, OR 640 PPM.
  • 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99004)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 2000, 5000, 8000, 11000, OR 14000 PPM.
  • 1 to 17 GD Teratology Pilot Studies (Dosed-Feed)  (TRP99005)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 1400, 2600, 3800, 5000, OR 6200 PPM.