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Testing Status of Boric acid 10035-D

 

CASRN: 10043-35-3

Formula: B-H3-O3

Synonyms/Common Names

  • Boracic acid

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C56417)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 1,200, 2,500, 5,000, 10,000, or 20,000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C56417)  Completed 
    • TR-324 (NIH Number: 88-2580)  (Peer Review Approval 03/26/1986A )
      Toxicology and Carcinogenesis Studies of Boric Acid (CASRN 10043-35-3) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG10035)  Completed 
    • Citation: Watson ATD, Sutherland VL, Cunny H, Miller-Pinsler L, Furr J, Hebert C, Collins B, Waidyanatha S, Smith L, Vinke T, Aillon K, Xie G, Shockley KR, McIntyre BS. Postnatal Effects of Gestational and Lactational Gavage Exposure to Boric Acid in the Developing Sprague Dawley Rat. Toxicol Sci. 2020 Jul 1;176(1):65-73. https://doi.org/10.1093/toxsci/kfaa061.
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5, 10, 20 mg/kg/day.
  • GD 6 to PND 120 F0 Generation (Gavage)  (MOG10035B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 4, 8, 12, 16 mg/kg/day.

Special Studies

  • Absorption Distribution Metabolism Excretion (Dosed-Feed)  (S0787)  Completed 
    • Citation: Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):145-51.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0, 9000 ppm (w/w) boric acid (1575 ppm boron).
  • Mechanisms (Dosed-Feed)  (S0788)  Completed 
    • Citation: Ku WW, Chapin RE, Wine RN, Gladen BC. Testicular toxicity of boric acid (BA): relationship of dose to lesion development and recovery in the F344 rat. Reprod Toxicol. 1993 Jul-Aug;7(4):305-19.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0, 3000, 4500, 6000, 9000 ppm.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (153962)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (621739)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (683471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (789471)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88034)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, 1000, 4500, 9000 PPM; 0, 4500 PPM; 0, 1000 PPM.
  • 0 to 20 GD Conventional Teratology (Dosed-Feed)  (TER89027)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .1, .2, .4, .8%.
  • 1 to 17 GD Conventional Teratology (Dosed-Feed)  (TER89028)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.1, 0.2, 0.4%.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER90003)  Completed 
    • Female Rabbits: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 62.5, 125, 250 MG/KG/DAY.
  • 14 to 17 GD Conventional Teratology (Dosed-Feed)  (TER90123)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 0.8, 1.6, 2.4% AND PAIR FED CONTROL FOR 2.4%.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER93138)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, .4, .5, .6, .8% *.