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Toxicology/Carcinogenicity

Female scientist looking through a microscope in a laboratory

Study Overview

Study: Short-term toxicity, long-term carcinogenicity
Species: Rats, mice

Description

NTP performs toxicology/carcinogenicity studies to address the gap in knowledge concerning the toxicity of substances in our environment. These studies are also performed to evaluate dose-response relationships between exposed and unexposed organisms and to determine if a substance elicits toxic effects and/or causes cancer in a biological system.

There are two categories of toxicology/carcinogenicity studies:

  • Short-term 14-day and 13-week toxicity studies 
  • Long-term 2-year studies 

These studies are performed according to the NTP Specifications for Toxicology/Carcinogenicity Studies.

General toxicology screens are typically carried out as contracted studies at several commercial laboratories in the U.S. These short-term studies usually involve exposing rats and mice of both sexes to a substance for a period of 14 days or 13 weeks. Typical assessments performed may include the following:

  • Clinical pathology
  • Measurements of estrous cycle length
  • Sperm motility
  • Tissue histopathology

Additional assessments may include:

  • Genotoxicity testing (e.g., assessing the frequency of micronucleated red blood cells)
  • Neurotoxicity testing (e.g., Functional Observational Battery)

Long-term NTP studies usually involve exposing both sexes of Harlan Sprague Dawley rats and B6C3F1/N hybrid mice to a substance for a period of 2 years. These two-year toxicology and carcinogenicity studies in rodents are the primary method NTP uses to identify substances that are hazardous to human health. Rodent studies along with epidemiology studies are the best way to identify potential human health hazards. Data from NTP rodent studies is used in risk assessments and contributes to the information used by regulatory agencies, such as the EPA, to establish regulations that protect human health.

For some substances, rats are exposed during the perinatal phase prior to a 13-week or 2-year study. The perinatal phase includes a gestation period (in utero via the placenta) and a lactation period (via the mother's milk). Perinatal exposure occurs during a critical developmental period, and toxicology/carcinogenicity results from this phase can differ from adulthood exposure results.

Protocols

The content on this page is a summary. For more detailed information, please see the NTP Specifications.

14-Day Toxicity Study

The 14-day toxicity protocol identifies potential target organs and toxicities, and assists in setting doses for the 13-week exposure study.

1. Treatment

After a 10- to 14-day quarantine period, animals are assigned at random to treatment groups including:

  • Five treatment groups each administered a different concentration of the test substance
  • One control group

Each group per sex per species contains five animals. Male mice are housed individually, while rats of both sexes and female mice are housed in groups of five animals per cage. For inhalation and dermal exposure studies, all rats and mice are housed individually.

Study animals receive the test substance through a designated route of exposure and the control animals receive vehicle alone. Exposure days are as follows:

  • 14 consecutive days for dosed-feed and dosed-water studies
  • 12 treatment days for inhalation, gavage, and dermal studies
Doses per animal/sex/species
  Animals   Sexes   Species   Test Groups   Total
Treatment 5 2 2 5 100
Controls 5 2 2 1 20
Total: 120

2. Observations

Animals are individually weighed on days one and seven, and at sacrifice. All animals are observed twice daily for clinical signs of pharmacologic and toxic effects of the test substance, declining health, or death. Animals found near death or showing clinical signs of pain or distress are humanely euthanized.

For dosed-feed or dosed-water studies, food consumption/water consumption is measured and recorded weekly.

3. Necropsy and Histopathologic Evaluation

Liver, thymus, right kidney, right testicle, heart, and lung weights are recorded for all animals surviving until the end of the study.

A complete necropsy is performed on all treated and control animals and all tissues are saved. See necropsy list.

Histopathologic evaluation is done only on those organs/tissues showing gross evidence of treatment-related lesions to a no-effect level. Corresponding tissues are evaluated in control animals. If specific targets are required, they are read in the control and highest treatment group and the remaining groups to a no-effect level.

13-Week Toxicity Study

13-week toxicity studies yield toxicological data that is used to determine the treatments for each strain and species for the 2-year toxicology/carcinogenicity studies.

1. Treatment

After a 10- to 14-day quarantine period, animals are assigned at random to treatment groups including:

  • Five treatment groups, each administered a different concentration of the test substance
  • One control group

Each group contains 10 animals per sex per species. Male mice are housed individually, while rats of both sexes and female mice are housed in groups of five animals per cage. For inhalation and dermal exposure studies, all rats and mice are housed individually.

Study animals receive the test substance through a designated route of exposure and the control animals receive vehicle alone. Exposure days are as follows:

  • 90 days for dosed-feed and dosed-water studies
  • 5 times per week (weekdays only, until the day prior to necropsy) for inhalation, gavage, and dermal studies
Doses per animal/sex/species
  Animals   Sexes   Species   Test Groups   Total
Treatment 10 2 2 5 200
Controls 10 2 2 1 40
Rats for special lab studies 10 2 1 5 100
Special controls for clinical lab studies 10 2 1 1 20
Total: 360

2. Observations

Animals are individually weighed on days one, seven, and at weekly periods thereafter. All animals are observed twice daily for clinical signs of declining health, or death. Animals found near death or showing clinical signs of pain or distress are humanely euthanized.

Formal clinical observations are performed and recorded weekly. For dosed-feed or dosed-water studies, food consumption/water consumption is measured and recorded weekly.

3. Necropsy and Histopathologic Evaluation

Liver, thymus, right kidney, right testis, heart, and lung weights are recorded from all animals surviving until the end of the study.

A complete necropsy is performed on all treated and control animals, and all tissues required for complete histopathology are trimmed, embedded, sectioned, and stained with hematoxylin and eosin for histopathologic evaluation. See necropsy list.

A complete histopathologic evaluation inclusive of treatment-related gross lesions shall be done on all animals. Treatment-related lesions for target organs shall be identified and these organs plus gross lesions shall be examined to a no-effect level. See list of tissues.

Specific Toxicologic Parameters Evaluated in the 13-Week Study

  1. Clinical Laboratory Studies

    Blood is collected from both sexes of "special study" rats, at days 4 ± 1 and 21 ± 2 and from the core study rats at the end of the study. These are processed for hematology and clinical chemistry determinations. Blood is collected from core study mice at the end of the study for hematology determinations. See clinical measurements.

  2. Blood for Micronuclei

    Blood samples are taken from mice and rats at study termination for micronuclei determinations.

  3. Sperm Morphology and Vaginal Cytology Evaluations (SMVCE)

    SMVCE are conducted on core study rats and mice. Mortality, body weight changes and clinical signs of toxicity are used to determine the 3 treatment groups used for the SMVC evaluations.

2-Year Study

2-year studies determine the toxicological and/or carcinogenic effects of long-term exposure of test substances in rats and mice.

1. Treatment

After a 10- to 14-day quarantine period, animals are assigned at random to treatment groups. Male mice are housed individually, while rats and female mice are group-housed. For inhalation and dermal exposure studies, all rats and mice are housed individually.

Rats and mice receive the test substance for 104 weeks via a defined route of exposure at three treatment concentrations plus controls. Animals have continuous access to dosed-feed and dosed-water in exposure studies. For inhalation, gavage and dermal studies, animals are treated five times per week, weekdays only.

Doses per animal/sex/species
  Animals   Sexes   Species   Test Groups   Total
Treatment 50 2 2 3 600
Controls 50 2 2 1 200
Sentinel Animals 15 2 2 - 60
Total: 860

2. Observations

Animals are individually weighed on day one and at 4-week intervals thereafter. Animals in dosed-feed and dosed-water studies are weighed weekly for the first 13 weeks and monthly thereafter. If life-threatening tumors develop, a significant number of deaths occur, or a significant effect on body weight is observed, the weighing frequency may be increased to every two weeks.

Animals are individually weighed on days one, seven, and at weekly periods thereafter. All animals are observed twice daily for clinical signs of declining health, or death. Animals found near death or showing clinical signs of pain or distress are humanely euthanized.

Formal examinations for clinical signs of toxicity are made and recorded at 4-week intervals. For dosed-feed or dosed-water studies, food consumption/water consumption is measured and recorded weekly for the first 13 weeks and monthly thereafter.

3. Necropsy and Pathology

A complete necropsy is performed on all treated and control animals and all tissues required for complete histopathology are trimmed, embedded, sectioned and stained with hematoxylin and eosin for histopathologic evaluation. See necropsy list.

All animals in all treatment groups that die and those that complete the 104-week exposure are subjected to a complete necropsy. Slides of all tissues required for complete histopathologic evaluation are prepared and evaluated. See histopathology list.

Levels of Evidence Criteria

Cancer Evaluation Criteria

The Levels of Evidence are used in the NTP Technical Report series to summarize the strength of carcinogenic activity observed in each experiment. They are divided into five categories. The categories were adopted in June 1983 and revised in March 1986 to specifically incorporate the strength of evidence of carcinogenic activity. The weight of the experimental evidence is dependent on the substance, as each substance elicits a different response in the animal. For each separate experiment (female rats, male rats, female mice, male mice), one of the following five categories describes the findings:

Categories for positive experimental results:

Clear Evidence of Carcinogenic Activity
Some Evidence of Carcinogenic Activity

Category for uncertain experimental results:

Equivocal Evidence of Carcinogenic Activity

Category for no observable effects:

No Evidence of Carcinogenic Activity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Carcinogenic Activity

When evaluations fall between two categories, factors that extend the boundary of an individual category of evidence are considered to generate a conclusion statement for a particular experiment. The following examples are factors that should be taken into consideration:

  • Occurrence of common vs. uncommon neoplasia
  • Progression (or lack thereof) from benign to malignant neoplasia as well as from preneoplastic to neoplastic lesions
  • Supporting information from proliferative lesions (hyperplasia) in the same site of neoplasia or in other experiments (same lesion in another sex or species)
  • Presence or absence of dose relationships
  • Statistical significance of the observed tumor increase
  • Concurrent control of tumor incidence, historical control rate, and variability for a specific neoplasm

Specifications & Guidance

Abstracts & Reports

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Listing of NTP study abstracts and reports
Abstract Full Text Report Title Report Year Type
TOX-95 Not yet available NTP Toxicity Report on Myristicin (CASRN 607-91-0) Administered to F344/NTac Rats and B6C3F1 Mice - In progress. N/A Short-Term Toxicity
TOX-94 Not yet available NTP Toxicity Report on 1020 Long Multiwalled Carbon Nanotubes (CASRN L-MWNT-1020) Administered to Sprague-Dawley Rats and B6C3F1/N Mice (Inhalation Study) - In progress. N/A Short-Term Toxicity
TOX-93 Not yet available NTP Toxicity Report on Chitosan (CASRN 9012-76-4) Administered to Sprague-Dawley Rats (Dosed-Feed Study) - In progress. N/A Short-Term Toxicity
TOX-92 PDF (5MB) NTP Technical Report on the Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice 2016 Short-Term Toxicity
TOX-91 Not yet available Toxicity Studies of Abrasive Blasting Agents Blasting Sand and Specular Hematite (CASRN BLASTINGSAND and HEMATITESPEC) Administered by Inhalation to F344/NTac and Harlan Sprague-Dawley - In progress. N/A Short-Term Toxicity
TOX-90 Not yet available Toxicity Studies of PCN 66/67 Comparison (CASRN PCNCOMPARISN) Administered by Gavage to Harlan Sprague-Dawley Rats - In progress. N/A Short-Term Toxicity
TOX-89 PDF (2MB) NTP Technical Report on the Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice 2015 Short-Term Toxicity
TOX-88 PDF (2MB) NTP Technical Report on the Toxicity Studies of p-Toluenesulfonamide Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice (CASRN 70-55-3) 2016 Short-Term Toxicity
TOX-87 Not yet available Toxicity Studies of Nanoscale material (Fullerene-C60 50 nanometers and Fullerene-C60 1 micron) Administered by Inhalation to Wistar Han Rats and B6C3F1 Mice (CASRN 99685-96-8) - In progress. N/A Short-Term Toxicity
TOX-86 PDF (8MB) NTP Technical Report on the Toxicity Studies of Cedarwood Oil (CASRN 8000-27-9) Cedarwood Oil (Virginia) Administered Dermally to F344/N Rats and B6C3F1/N Mice 2016 Short-Term Toxicity
TOX-85 Not yet available Toxicity Studies of Tetabromobisphenol A-bis (2,3 – dibromoproply ether) Administered by Gavage to F344/NTac Rats and B6C3F1 Mice (CASRN 21850-44-2) - In progress. N/A Short-Term Toxicity
TOX-84 Not yet available Toxicity Study of ortho-Phthalaldehyde (CASRN 643-79-8) 90 Day Inhalation - In progress. N/A Short-Term Toxicity
TOX-83 PDF (3MB) Toxicity Studies of o-Chloropyridine (CASRN 109-09-1) Administered by Dosed-Water to F344/N Rats and B6C3F1 Mice 2017 Short-Term Toxicity
TOX-82 PDF (3MB) 3-Month Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2011 Short-Term Toxicity
TOX-81 PDF (6MB) NTP Technical Report on the Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice 2016 Short-Term Toxicity
TOX-80 PDF (2MB) NTP Technical Report on the Toxicity Studies of Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally to F344/N Rats and B6C3F1/N Mice 2016 Short-Term Toxicity
TOX-79 PDF (2MB) NTP Toxicity Report on the Reproductive Dose Range-Finding Study of Genistein (CASRN 446-72-0) Administered in Feed to Sprague-Dawley Rats 2008 Short-Term Toxicity
TOX-78 Not yet available Toxicity Studies of Triethylamine (CASRN 121-44-8) Administered by Inhalation to F344/N Rats and B6C3F1 Mice - In progress. N/A Short-Term Toxicity
TOX-77 Not yet available Toxicity Studies of Hexachlorobenzene - In progress. N/A Short-Term Toxicity
TOX-76 PDF (6MB) Toxicity Studies of 2,4-Decadienal (CASRN 25152-84-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2011 Short-Term Toxicity
TOX-75 PDF (1MB) Toxicity Studies of Dimethylaminopropyl Chloride, Hydrochloride (CASRN 5407-04-5) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2007 Short-Term Toxicity
TOX-74 PDF (7MB) Toxicity Study Report of Cellulose Insulation; Atmospheric Characterization, Particle Size, Chemical Composition, and Workplace Exposure Assessment 2006 Short-Term Toxicity
TOX-73 PDF (2MB) Metabolism, Toxicity, and Predicted Carcinogenicity Studies of Diazoaminobenzene (CASRN 136-35-6) Administered Dermally to F344/N Rats and B6C3F1 Mice 2002 Short-Term Toxicity
TOX-72 PDF (14MB) Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice 2007 Short-Term Toxicity
TOX-71 PDF (1MB) Toxicity Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) Administered in Feed to F344/N Rats and B6C3F1 Mice 2004 Short-Term Toxicity
TOX-70 PDF (4MB) Toxicity Studies of p-tert-Butylcatechol (CASRN 98-29-3) Administered in Feed to F344/N Rats and B6C3F1 Mice 2002 Short-Term Toxicity
TOX-69 PDF (3MB) Toxicity Studies of Butanal Oxime (CASRN 110-69-0) Administered in Drinking Water and by Gavage to F344/N Rats and B6C3F1 Mice 2004 Short-Term Toxicity
TOX-67 PDF (4MB) Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1 Mice (CASRN 693-98-1 and 822-36-6) 2004 Short-Term Toxicity
TOX-66 PDF (3MB) Toxicity Studies of 3,3',4,4'-Tetrachloroazoxybenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice (CASRN 21232-47-3) 1998 Short-Term Toxicity
TOX-65 PDF (2MB) Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice (CASRN 14047-09-7) 1998 Short-Term Toxicity
TOX-62 PDF (2MB) Toxicity Studies of WY-14,643 (CASRN 50892-23-4) Administered in Feed to Sprague-Dawley Rats, B6C3F1 Mice, and Syrian Hamsters 2007 Short-Term Toxicity
TOX-61 PDF (2MB) Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1 Mice (CASRN 119-61-9) 2000 Short-Term Toxicity
TOX-60 N/A Toxicity Studies of Dibutyl Phthalate - No technical report issued. N/A Short-Term Toxicity
TOX-59 PDF (10MB) Toxicity and Metabolism Studies of Chloral Hydrate (CASRN 302-17-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1999 Short-Term Toxicity
TOX-58 PDF (2MB) Toxicity Studies of 60-Hz Magnetic Fields Administered by Whole Body Exposure to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice 1996 Short-Term Toxicity
TOX-57 PDF (2MB) Toxicity Studies of Benzyltrimethylammonium Chloride (CASRN 56-93-9) Administered by Gavage to F344/N Rats, Sprague-Dawley Rats, and B6C3F1 Mice 2000 Short-Term Toxicity
TOX-56 PDF (3MB) Toxicity Studies of Carisoprodol (CASRN 78-44-4) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2000 Short-Term Toxicity
TOX-55 PDF (3MB) Toxicity Studies of trans-1,2-Dichloroethylene (CASRN 156-60-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice 2002 Short-Term Toxicity
TOX-54 PDF (375KB) Summary Report on the Metabolism, Disposition and Toxicity of 1,4-Butanediol (CASRN 110-63-4) 1996 Short-Term Toxicity
TOX-53 PDF (4MB) Toxicity Studies oft-Butyl Alcohol Administered in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (CASRN 75-65-0) 1997 Short-Term Toxicity
TOX-52 PDF (3MB) Toxicity Studies of Urethane in Drinking Water and Urethane in 5% Ethanol in F344/N Rats and B6C3F1 Mice (CASRN 51-79-6) 1996 Short-Term Toxicity
TOX-51 PDF (8MB) Toxicity Studies of Methyl Ethyl Ketoxime in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (CASRN 96-29-7) 1999 Short-Term Toxicity
TOX-50 PDF (2MB) Toxicity Studies of Cyclohexanone Oxime in B6C3F1 Mice (Drinking Water Studies) (CASRN 100-64-1) 1996 Short-Term Toxicity
TOX-49 PDF (2MB) Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CASRN 79-34-5) 2004 Short-Term Toxicity
TOX-48 PDF (16MB) Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2006 Short-Term Toxicity
TOX-47 PDF (2MB) Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1 Mice (CASRN 126-98-7) 2000 Short-Term Toxicity
TOX-46 PDF (2MB) Hepatoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride (CASRN 135-23-9) Administered in Feed to Male F344/N Rats 2000 Short-Term Toxicity
TOX-45 PDF (1MB) Renal Toxicity Studies of Selected Halogenated Ethanes Administered by Gavage to F344/N Rats 1996 Short-Term Toxicity
TOX-44 PDF (2MB) Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats 1996 Short-Term Toxicity
TOX-43 PDF (3MB) Comparative Toxicity Studies of o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9; and 106-47-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1998 Short-Term Toxicity
TOX-42 PDF (1MB) Toxicity Studies of 1,3-Diphenylguanidine (CASRN 102-06-7) Administered in Feed to F344/N Rats and B6C3F1 Mice 1995 Short-Term Toxicity
TOX-41 PDF (2MB) Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6) 2000 Short-Term Toxicity
TOX-40 PDF (2MB) Toxicity Studies of b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1994 Short-Term Toxicity
TOX-39 PDF (2MB) Toxicity Studies of Cadmium Oxide (CASRN 1306-19-0) Administered by Inhalation to F344/N Rats and B6C3F1 Mice 1995 Short-Term Toxicity
TOX-38 PDF (2MB) Toxicity Studies of Sodium Selenate and Sodium Selenite (CASRNs 13410-01-0 and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice. 1994 Short-Term Toxicity
TOX-37 PDF (591KB) Toxicity Studies of Sodium Cyanide, (CASRN 143-33-9) Administered by Dosed Water to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-36 PDF (5MB) Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-35 PDF (10MB) Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-34 PDF (838KB) Toxicity Studies of 1-Nitropyrene (CASRN 5522-43-0) Administered by Inhalation to F344/N Rats 1996 Short-Term Toxicity
TOX-33 PDF (9MB) Toxicity Studies of 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene (CASRN 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-32 PDF (3MB) Toxicity Studies of Methylene bis(thiocyanate), (CASRN 6317-18-6) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-31 PDF (7MB) Toxicity Studies of Isoprene (CASRN 78-79-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice 1995 Short-Term Toxicity
TOX-30 PDF (2MB) Toxicity Studies of Dibutyl Phthalate (CASRN 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice 1995 Short-Term Toxicity
TOX-29 PDF (6MB) Toxicity Studies of Cupric Sulfate (CASRN 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-28 PDF (820KB) Toxicity Studies of Tetrachlorophthalic Anhydride (CASRN 117-08-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-27 PDF (2MB) Toxicity Studies of Riddelliine (CASRN 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1 Mice. 1993 Short-Term Toxicity
TOX-26 PDF (8MB) Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-25 PDF (2MB) Toxicity Studies of Glutaraldehyde (CASRN 111-30-8) Adminstered by Inhalation to F344/N Rats and B6C3F1 Mice. 1993 Short-Term Toxicity
TOX-24 PDF (1MB) Toxicity Studies of 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) Administered by Drinking Water and Inhalation to F344/N Rats and B6C3F1 Mice 1993 Short-Term Toxicity
TOX-23 PDF (6MB) Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-22 PDF (2MB) Toxicity Studies of N,N-Dimethylformamide (CASRN 68-12-2) Administered by Inhalation to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-21 PDF (20MB) Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-20 PDF (2MB) Toxicity Studies of Diethanolamine (CASRN 111-42-2) Administered Topically and in Drinking Water to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-19 PDF (1MB) Toxicity Studies of Formic Acid (CASRN 64-18-6) Administered by Inhalation to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-18 PDF (4MB) Toxicity Studies of Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) in Dimethyl Phthalate (CASRN 131-11-3) (45:55) 1993 Short-Term Toxicity
TOX-17 PDF (1MB) Toxicity Studies of Black Newsprint Inks Administered Topically to F344/N Rats and C3H Mice 1992 Short-Term Toxicity
TOX-16 PDF (2MB) Toxicity Studies of Glyphosate (CASRN 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-15 PDF (726KB) Toxicity Studies of t-Butyl Perbenzoate (CASRN 614-45-9) Administered by Gavage to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-14 PDF (2MB) Toxicity Studies of p-Chloro-a,a,a-Trifluorotoluene (CASRN: 98-56-6) Administered in Corn Oil and a-Cyclodextrin to F344/N Rats and B6C3F1 Mice in 14-Day Comparative Gavage Studies 1992 Short-Term Toxicity
TOX-13 PDF (2MB) Toxicity Studies of Trinitrofluorenone (CASRN 129-79-3) Administered by Topical Application and Dosed Feed to F344/N Rats and B6C3F1 Mice 1992 Short-Term Toxicity
TOX-12 PDF (240KB) Toxicity Studies of Castor Oil (CASRN 8001-79-4) in F344/N Rats and B6C3F1 Mice (Dosed Feed Studies) 1992 Short-Term Toxicity
TOX-11 PDF (2MB) Toxicity Studies of Antimony Potassium Tartrate (CASRN 28300-74-5) in F344/N Rats and B6C3F1 Mice (Drinking Water and Intraperitoneal Injection Studies) 1992 Short-Term Toxicity
TOX-10 PDF (3MB) Toxicity Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1992 Short-Term Toxicity
TOX-09 PDF (6MB) Toxicity Studies of Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Short-Term Toxicity
TOX-08 PDF (2MB) Toxicity Studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 8003-22-3) 1991 Short-Term Toxicity
TOX-07 PDF (4MB) Toxicity Studies of 1,2,4,5-Tetrachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 95-94-3) 1991 Short-Term Toxicity
TOX-06 PDF (4MB) Toxicity Studies of Pentachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CASRN 608-93-5) 1991 Short-Term Toxicity
TOX-05 PDF (3MB) Toxicity Studies of Cobalt Sulfate Heptahydrate in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (CASRN 10026-24-1) 1991 Short-Term Toxicity
TOX-04 PDF (4MB) Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2) 1991 Short-Term Toxicity
TOX-03 PDF (3MB) Toxicity Studies of Acetone in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (CASRN 67-64-1) 1991 Short-Term Toxicity
TOX-02 PDF (2MB) Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CASRN 110-54-3) 1991 Short-Term Toxicity
TOX-01 PDF (322KB) Toxicity Studies of Hexachloro-1,3-butadiene in B6C3F1 Mice (Feed Studies) (CASRN 87-68-3) 1991 Short-Term Toxicity
TR-594 Draft (13MB) Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies) N/A Long-Term Carcinogenicity
TR-593 Draft (22MB) Toxicology and Carcinogenesis Studies of 2,3-Butanedione (CASRN 431-03-8) in Wistar Han [Crl:WI (Han)] Rats and B6C3F1/N Mice (Inhalation Studies) N/A Long-Term Carcinogenicity
TR-592 Draft (3MB) Toxicology and Carcinogenesis Study of Dietary Zinc (CASRN 5263-02-5) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Studies) N/A Long-Term Carcinogenicity
TR-591 PDF (17MB) Toxicology and Carcinogenesis Studies of Trim® VX (CASRN TRIMVX) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies) 2016 Long-Term Carcinogenicity
TR-590 Draft (19MB) Toxicology and Carcinogenesis Studies of Antimony Trioxide (CASRN 1309-64-4) in Wistar Han Rats and B6C3F Mice (Inhalation Studies) N/A Long-Term Carcinogenicity
TR-589 PDF (14MB) Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2016 Long-Term Carcinogenicity
TR-588 PDF (4MB) Toxicology and Carcinogenesis Studies of Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and B6C3F1/Nctr Mice (Drinking Water Studies) 2014 Long-Term Carcinogenicity
TR-587 PDF (4MB) Toxicology Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2014 Long-Term Carcinogenicity
TR-586 PDF (4MB) Toxicology and Carcinogenesis Studies of CIMSTAR® 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies) 2015 Long-Term Carcinogenicity
TR-585 PDF (6MB) Toxicology Studies of Green Tea Extract (CASRN GREENTEAEXTR) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) 2016 Long-Term Carcinogenicity
TR-584 Draft (24MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies) N/A Long-Term Carcinogenicity
TR-583 PDF (8MB) Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies) 2015 Long-Term Carcinogenicity
TR-582 PDF (7MB) Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2015 Long-Term Carcinogenicity
TR-581 PDF (19MB) Toxicology Studies of Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Cobalt Metal in F344/NTac Rats and B6C3F1/N Mice (Inhalation Studies) 2014 Long-Term Carcinogenicity
TR-580 PDF (3MB) Toxicology and Carcinogenesis Studies of β-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2014 Long-Term Carcinogenicity
TR-579 PDF (12MB) Toxicology and Carinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) 2012 Long-Term Carcinogenicity
TR-578 PDF (8MB) Toxicology and Carcinogenesis Studies of Ginkgo Biloba Extract (CASRN 90045-36-6) in F344/N Rats and B6C3F1/N Mice (Gavage Studies) 2013 Long-Term Carcinogenicity
TR-577 PDF (5MB) Toxicology and Carcinogenesis Studies of a Nondecolorized Whole Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) (CASRN ALOEVLEAFEXT) in F344/N Rats and B6C3F1 Mice (Drinking Water Study) 2013 Long-Term Carcinogenicity
TR-576 PDF (6MB) Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies) 2012 Long-Term Carcinogenicity
TR-575 PDF (10MB) Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies) 2012 Long-Term Carcinogenicity
TR-574 PDF (13MB) Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies) 2013 Long-Term Carcinogenicity
TR-573 PDF (6MB) Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies) 2012 Long-Term Carcinogenicity
TR-572 PDF (9MB) Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CASRN 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies) 2012 Long-Term Carcinogenicity
TR-571 PDF (12MB) Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2012 Long-Term Carcinogenicity
TR-570 PDF (15MB) Toxicology and Carcinogenesis Studies of α,β-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Long-Term Carcinogenicity
TR-569 PDF (8MB) Toxicology and Carcinogenesis Studies of Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine (3TC), Nevirapine (NVP), and Nelfinavir Mesylate (NFV) (CASRNs 30516-87-1, 134678-17-4, 129618-40-2, 159989-65-8) in B6C3F1 Mice (Transplacental Exposure Studies) 2013 Long-Term Carcinogenicity
TR-568 PDF (19MB) Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate [CASRN 302-79-4 (All-trans-retinoic acid) and 79-81-2 (All-trans-retinyl palmitate)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study) 2012 Long-Term Carcinogenicity
TR-567 PDF (7MB) Toxicology and Carcinogenesis Studies of Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Long-Term Carcinogenicity
TR-566 PDF (9MB) Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies) 2011 Long-Term Carcinogenicity
TR-565 PDF (8MB) Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies) 2011 Long-Term Carcinogenicity
TR-564 PDF (9MB) Toxicology and Carcinogenesis Studies of 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies) 2011 Long-Term Carcinogenicity
TR-563 PDF (11MB) Toxicology and Carcinogenesis Studies of Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2011 Long-Term Carcinogenicity
TR-562 PDF (6MB) Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies) 2010 Long-Term Carcinogenicity
TR-561 PDF (14MB) Toxicology and Carcinogenesis Studies of Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2011 Long-Term Carcinogenicity
TR-560 PDF (7MB) Toxicology and Carcinogenesis Studies of Androstenedione (CASRN 63-05-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2010 Long-Term Carcinogenicity
TR-559 PDF (6MB) Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies) 2010 Long-Term Carcinogenicity
TR-558 PDF (22MB) Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies) 2010 Long-Term Carcinogenicity
TR-557 PDF (16MB) Toxicology and Carcinogenesis Studies of beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2010 Long-Term Carcinogenicity
TR-556 PDF (6MB) Toxicology and Carcinogenesis Studies of Chromium Picolinate Monohydrate (CASRN 27882-76-4) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2010 Long-Term Carcinogenicity
TR-555 PDF (6MB) Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2010 Long-Term Carcinogenicity
TR-554 PDF (7MB) Toxicology and Carcinogenesis Studies of 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2010 Long-Term Carcinogenicity
TR-553 PDF (7MB) Photococarcinogenesis Study of Aloe Vera [CASRN 481-72-1 (Aloe-emodin)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study) 2010 Long-Term Carcinogenicity
TR-552 PDF (3MB) Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2008 Long-Term Carcinogenicity
TR-551 PDF (6MB) NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies) 2010 Long-Term Carcinogenicity
TR-550 PDF (3MB) Toxicology and Carcinogenesis Studies of Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies) 2008 Long-Term Carcinogenicity
TR-549 PDF (20MB) Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CASRN 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies) 2009 Long-Term Carcinogenicity
TR-548 PDF (7MB) Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) 2010 Long-Term Carcinogenicity
TR-547 PDF (8MB) Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies) 2010 Long-Term Carcinogenicity
TR-546 PDF (9MB) Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2008 Long-Term Carcinogenicity
TR-545 PDF (12MB) Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study) 2008 Long-Term Carcinogenicity
TR-544 PDF (7MB) Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies) 2010 Long-Term Carcinogenicity
TR-543 PDF (9MB) Toxicology and Carcinogenesis Studies of α-Methylstyrene (CASRN 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2007 Long-Term Carcinogenicity
TR-542 PDF (9MB) Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2009 Long-Term Carcinogenicity
TR-541 PDF (3MB) Toxicology and Carcinogenesis Studies of Formamide (CASRN 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2008 Long-Term Carcinogenicity
TR-540 PDF (11MB) Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2008 Long-Term Carcinogenicity
TR-539 PDF (24MB) Multigenerational Reproductive Toxicology Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (Feed Study) 2008 Long-Term Carcinogenicity
TR-538 PDF (14MB) Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2007 Long-Term Carcinogenicity
TR-537 PDF (9MB) Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2007 Long-Term Carcinogenicity
TR-536 PDF (9MB) Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2011 Long-Term Carcinogenicity
TR-535 PDF (10MB) Toxicology and Carcinogenesis Studies of 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2007 Long-Term Carcinogenicity
TR-534 PDF (10MB) Toxicology and Carcinogenesis Studies of Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2006 Long-Term Carcinogenicity
TR-533 PDF (11MB) Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2006 Long-Term Carcinogenicity
TR-532 PDF (7MB) Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies) 2006 Long-Term Carcinogenicity
TR-531 PDF (13MB) Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-530 PDF (13MB) Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-529 PDF (7MB) Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-528 PDF (6MB) Carcinogenesis Studies of 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane (CASRNs 3296-90-0, 75-52-5, and 96-18-4) in Guppies (Poecilia reticulata) and Medaka (Oryzias latipes) (Waterborne Studies) 2005 Long-Term Carcinogenicity
TR-527 PDF (8MB) Toxicology and Carcinogenesis Studies of Malachite Green Chloride and Leucomalachite Green (CASRNs 569-64-2 and 129-73-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2005 Long-Term Carcinogenicity
TR-526 PDF (9MB) Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-525 PDF (8MB) Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-524 PDF (17MB) Photocarcinogenesis Study of Glycolic Acid and Salicylic Acid (CASRNs 79-14-1 and 69-72-7) in SKH-1 Mice (Simulated Solar Light and Topical Application Studies) 2007 Long-Term Carcinogenicity
TR-523 PDF (10MB) Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2007 Long-Term Carcinogenicity
TR-522 PDF (6MB) Toxicology and Carcinogenesis Studies of Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1®) Mice (in utero Studies) 2006 Long-Term Carcinogenicity
TR-521 PDF (15MB) Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-520 PDF (16MB) Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies) 2006 Long-Term Carcinogenicity
TR-519 PDF (8MB) Toxicology and Carcinogenesis Studies of Stoddard Solvent IIC (CASRN 64742-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2004 Long-Term Carcinogenicity
TR-518 PDF (5MB) Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal Studies) 2004 Long-Term Carcinogenicity
TR-517 PDF (10MB) Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2005 Long-Term Carcinogenicity
TR-516 PDF (10MB) Toxicology and Carcinogenesis Studies of 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2004 Long-Term Carcinogenicity
TR-515 PDF (10MB) Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies) 2004 Long-Term Carcinogenicity
TR-514 PDF (9MB) Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2004 Long-Term Carcinogenicity
TR-513 PDF (12MB) Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies) 2005 Long-Term Carcinogenicity
TR-512 PDF (13MB) Toxicology and Carcinogenesis Studies of Elmiron® (CASRN 37319-17-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2004 Long-Term Carcinogenicity
TR-511 PDF (10MB) Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2004 Long-Term Carcinogenicity
TR-510 PDF (18MB) Toxicology and Carcinogenesis Studies of Urethane + Ethanol (CASRNs 51-79-6 & 64-17-5) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2004 Long-Term Carcinogenicity
TR-509 PDF (11MB) Toxicology and Carcinogenesis Studies of 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83-6; 11% cis,trans Isomer in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2003 Long-Term Carcinogenicity
TR-508 PDF (9MB) Toxicology and Carcinogenesis Studies of Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2003 Long-Term Carcinogenicity
TR-507 PDF (14MB) Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2002 Long-Term Carcinogenicity
TR-506 PDF (7MB) Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies) 2001 Long-Term Carcinogenicity
TR-505 PDF (11MB) Toxicology and Carcinogenesis Studies of Citral (Microencapsulated) (CASRN 5392-40-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2003 Long-Term Carcinogenicity
TR-504 PDF (6MB) Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2002 Long-Term Carcinogenicity
TR-503 PDF (5MB) Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CASRN 302-17-0) in Male B6C3F1 Mice (Gavage Study) 2003 Long-Term Carcinogenicity
TR-502 PDF (9MB) Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies) 2002 Long-Term Carcinogenicity
TR-501 PDF (13MB) Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2001 Long-Term Carcinogenicity
TR-500 PDF (9MB) Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation Studies) 2000 Long-Term Carcinogenicity
TR-499 PDF (19MB) Toxicology and Carcinogenesis Studies of Indium Phosphide (CASRN 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2001 Long-Term Carcinogenicity
TR-498 PDF (10MB) Toxicology and Carcinogenesis Studies of p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2002 Long-Term Carcinogenicity
TR-497 PDF (10MB) Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2001 Long-Term Carcinogenicity
TR-496 PDF (33MB) Toxicology and Carcinogenesis Studies of Fumonisin B1 (CASRN 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2001 Long-Term Carcinogenicity
TR-495 PDF (17MB) Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 2001 Long-Term Carcinogenicity
TR-494 PDF (16MB) Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2005 Long-Term Carcinogenicity
TR-493 PDF (18MB) Toxicology and Carcinogenesis Studies of Emodin (CASRN 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2001 Long-Term Carcinogenicity
TR-492 PDF (23MB) Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2000 Long-Term Carcinogenicity
TR-491 PDF (23MB) Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 2000 Long-Term Carcinogenicity
TR-490 PDF (11MB) Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-489 PDF (9MB) Studies of Magnetic Field Promotion (DMBA Initiation) in Sprague-Dawley Rats (Gavage/Whole-Body Exposure Studies) 1999 Long-Term Carcinogenicity
TR-488 PDF (21MB) Toxicology and Carcinogenesis Studies of 60-HZ Magnetic Fields in F344/N Rats and B6C3F1 Mice (Whole-Body Exposure Studies) 1999 Long-Term Carcinogenicity
TR-487 PDF (11MB) Toxicology and Carcinogenesis Studies of Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Long-Term Carcinogenicity
TR-486 PDF (12MB) Toxicology and Carcinogenesis Studies of Isoprene (CASRN 78-79-5) in F344/N Rats (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-485 PDF (12MB) Toxicology and Carcinogenesis Studies of Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies) 1999 Long-Term Carcinogenicity
TR-484 PDF (12MB) Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 2000 Long-Term Carcinogenicity
TR-483 PDF (8MB) Toxicology and Carcinogenesis Studies of Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed Studies) 1999 Long-Term Carcinogenicity
TR-482 PDF (28MB) Toxicology and Carcinogenesis Studies of Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-481 PDF (8MB) Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CASRN 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1999 Long-Term Carcinogenicity
TR-480 PDF (8MB) Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CASRN 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1999 Long-Term Carcinogenicity
TR-479 PDF (8MB) Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 2001 Long-Term Carcinogenicity
TR-478 PDF (10MB) Toxicology and Carcinogenesis Studies of Diethanolamine (CASRN 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1999 Long-Term Carcinogenicity
TR-477 PDF (10MB) Toxicology and Carcinogenesis Studies of 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1998 Long-Term Carcinogenicity
TR-476 PDF (13MB) Toxicology and Carcinogenesis Studies of Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2000 Long-Term Carcinogenicity
TR-475 PDF (10MB) Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Long-Term Carcinogenicity
TR-474 PDF (4MB) Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CASRN 9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies) 1998 Long-Term Carcinogenicity
TR-473 PDF (11MB) Toxicology and Carcinogenesis Studies of Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) 1998 Long-Term Carcinogenicity
TR-472 PDF (11MB) Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-471 PDF (13MB) Toxicology and Carcinogenesis Studies of Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Long-Term Carcinogenicity
TR-470 PDF (16MB) Toxicology and Carcinogenesis Studies of Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies) 2000 Long-Term Carcinogenicity
TR-469 PDF (16MB) Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies) 1999 Long-Term Carcinogenicity
TR-468 PDF (7MB) Toxicology and Carcinogenesis Studies of Oxazepam (CASRN 604-75-1) in F344/N Rats (Feed Studies) 1998 Long-Term Carcinogenicity
TR-467 PDF (15MB) Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Long-Term Carcinogenicity
TR-466 PDF (12MB) Toxicology and Carcinogenesis Studies of Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-465 PDF (19MB) Toxicology and Carcinogenesis Studies of Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1 Mice (Feed Studies) 1996 Long-Term Carcinogenicity
TR-464 PDF (10MB) Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CASRN 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies) 1998 Long-Term Carcinogenicity
TR-463 PDF (13MB) Toxicology and Carcinogenesis Studies of D&C Yellow No. 11 (CASRN 8003-22-3) in F344 Rats (Feed Studies) 1997 Long-Term Carcinogenicity
TR-462 PDF (26MB) Toxicology and Carcinogenesis Studies of Molybdenum Trioxide (CASRN 1313-27-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1997 Long-Term Carcinogenicity
TR-461 PDF (21MB) Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1997 Long-Term Carcinogenicity
TR-460 PDF (30MB) Effects of Dietary Restrictions on Toxicology and Carcinogenesis Studies of in F344 Rats and B6C3F1 Mice 1997 Long-Term Carcinogenicity
TR-459 PDF (25MB) Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies) 1997 Long-Term Carcinogenicity
TR-458 PDF (12MB) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats (Feed Studies) 1997 Long-Term Carcinogenicity
TR-457 PDF (19MB) Toxicology and Carcinogenesis Studies of Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1997 Long-Term Carcinogenicity
TR-456 PDF (18MB) Toxicology and Carcinogenesis Studies of 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) and the Initiation/Promotion (Dermal Study) in Female Sencar Mice 1997 Long-Term Carcinogenicity
TR-455 PDF (15MB) Toxicology and Carcinogenesis Studies of Codeine (CASRN 76-57-3) in F344 Rats and B6C3F1 Mice (Feed Studies) 1996 Long-Term Carcinogenicity
TR-454 PDF (19MB) Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1996 Long-Term Carcinogenicity
TR-453 PDF (18MB) Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1996 Long-Term Carcinogenicity
TR-452 PDF (31MB) Toxicology and Carcinogenesis Studies of 2,2-Bis(Bromomethyl)-1,3-Propanediol (FR-1138 ®) (CASRN 3296-90-0) in F344 Rats and B6C3F1 Mice (Feed Studies) 1996 Long-Term Carcinogenicity
TR-451 PDF (28MB) Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1996 Long-Term Carcinogenicity
TR-450 PDF (22MB) Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1997 Long-Term Carcinogenicity
TR-449 PDF (10MB) Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1999 Long-Term Carcinogenicity
TR-448 PDF (22MB) Toxicology and Carcinogenesis Studies of Isobutyl Nitrite (CASRN 542-56-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies) 1996 Long-Term Carcinogenicity
TR-447 PDF (14MB) Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1996 Long-Term Carcinogenicity
TR-446 PDF (16MB) Toxicology and Carcinogenesis Studies of 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1996 Long-Term Carcinogenicity
TR-445 PDF (13MB) Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CASRN 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1997 Long-Term Carcinogenicity
TR-444 PDF (6MB) Initiation/Promotion Study ofo-Benzyl-p-Chlorophenol (CASRN120-32-1) in Swiss (CD-1®) Mice (Mouse Skin Study) 1995 Long-Term Carcinogenicity
TR-443 PDF (16MB) Toxicology and Carcinogenesis Studies of Oxazepam (CASRN 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-442 PDF (16MB) Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1994 Long-Term Carcinogenicity
TR-441 PDF (12MB) Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice 1996 Long-Term Carcinogenicity
TR-440 PDF (17MB) Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1994 Long-Term Carcinogenicity
TR-439 PDF (15MB) Toxicology and Carcinogenesis Studies of Methylphenidate Hydrochloride (CASRN 298-59-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1995 Long-Term Carcinogenicity
TR-438 PDF (10MB) Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CASRN 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1995 Long-Term Carcinogenicity
TR-437 PDF (16MB) Toxicology and Carcinogenesis Studies of Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats and B6C3F1 Mice (inhalation studies) 1994 Long-Term Carcinogenicity
TR-436 PDF (17MB) Toxicology and Carcinogenesis Studies of t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1995 Long-Term Carcinogenicity
TR-435 PDF (16MB) Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1994 Long-Term Carcinogenicity
TR-434 PDF (21MB) Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies) 1993 Long-Term Carcinogenicity
TR-433 PDF (24MB) Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies) 1994 Long-Term Carcinogenicity
TR-432 PDF (15MB) Toxicology and Carcinogenesis Studies of Barium Chloride Dihydrate (CASRN 10326-27-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1994 Long-Term Carcinogenicity
TR-431 PDF (15MB) Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice Feed Studies) 1993 Long-Term Carcinogenicity
TR-430 PDF (16MB) Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 (CASRN 28407-37-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1994 Long-Term Carcinogenicity
TR-429 PDF (12MB) Toxicology and Carcinogenesis Studies of Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate (CASRN 131-11-3) in Male Swiss (CD-1®) Mice 1995 Long-Term Carcinogenicity
TR-428 PDF (20MB) Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-427 PDF (16MB) Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CASRN 8024-37-1) (Major Component 79% Curcumin, CASRN 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-426 PDF (19MB) Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CASRNs 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage 1994 Long-Term Carcinogenicity
TR-425 PDF (23MB) Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride (CASRN 58-33-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-424 PDF (16MB) Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1994 Long-Term Carcinogenicity
TR-423 PDF (25MB) Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CASRN 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-422 PDF (19MB) Toxicology and Carcinogenesis Studies of Coumarin (CASRN 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-421 PDF (16MB) Toxicology and Carcinogenesis Studies of Talc (CASRN 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1993 Long-Term Carcinogenicity
TR-420 PDF (20MB) Toxicology and Carcinogenesis Studies of Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-419 PDF (11MB) Toxicology and Carcinogenesis Studies of HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-418 PDF (10MB) Toxicology and Carcinogenesis Studies of p-Nitroaniline (CASRN 100-01-6) in B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-417 PDF (7MB) Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice (Dermal Studies) 1993 Long-Term Carcinogenicity
TR-416 PDF (25MB) Toxicology and Carcinogenesis Studies of o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-415 PDF (12MB) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-414 PDF (15MB) Toxicology and Carcinogenesis Studies of Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-413 PDF (11MB) Toxicology and Carcinogenesis Studies of Ethylene Glycol (CASRN 107-21-1) in B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-412 PDF (11MB) Toxicology and Carcinogenesis Studies of 4,4'-Diamino-2,2'-Stilbenedisulfonic Acid Disodium Salt (CASRN 7336-20-1) in F344 Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-411 PDF (15MB) Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-410 PDF (9MB) Toxicology and Carcinogenesis Studies of Naphthalene (CASRN 91-20-3) in B6C3F1 Mice (Inhalation Studies) 1992 Long-Term Carcinogenicity
TR-409 PDF (10MB) Toxicology and Carcinogenesis Studies of Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies) 1992 Long-Term Carcinogenicity
TR-408 PDF (13MB) Toxicology and Carcinogenesis Studies of Mercuric Chloride (CASRN 7487-94-7) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-407 PDF (16MB) Toxicology and Carcinogenesis Studies of C.I. Pigment Red 3 (CASRN 2425-85-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-406 PDF (11MB) Toxicology and Carcinogenesis Studies of g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992 Long-Term Carcinogenicity
TR-405 PDF (13MB) Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CASRN 6459-94-5) in F344/N Rats (Drinking Water Studies) 1991 Long-Term Carcinogenicity
TR-404 PDF (14MB) Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-403 PDF (15MB) Toxicology and Carcinogenesis Studies of Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1992 Long-Term Carcinogenicity
TR-402 PDF (32MB) Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies) 1993 Long-Term Carcinogenicity
TR-401 PDF (12MB) NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CASRN 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992 Long-Term Carcinogenicity
TR-400 PDF (11MB) Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1993 Long-Term Carcinogenicity
TR-399 PDF (9MB) Toxicology and Carcinogenesis Studies of Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats (Gavage Studies) 1991 Long-Term Carcinogenicity
TR-398 PDF (15MB) Toxicology and Carcinogenesis Studies of Polybrominated Biphenyls (Firemaster FF-1") (CASRN 67774-32-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-397 PDF (14MB) Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CASRN 2429-74-5) in F344 Rats (Drinking Water Studies) 1992 Long-Term Carcinogenicity
TR-396 PDF (15MB) Toxicology and Carcinogenesis Studies of Monochloroacetic Acid (CASRN 79-11-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992 Long-Term Carcinogenicity
TR-395 PDF (17MB) Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1991 Long-Term Carcinogenicity
TR-394 PDF (14MB) Toxicology and Carcinogenesis Studies of Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-393 PDF (22MB) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies) 1990 Long-Term Carcinogenicity
TR-392 PDF (76MB) Toxicology and Carcinogenesis Studies of Chlorinated Water (CASRNs 7782-50-5 and 7681-52-9) and Chloraminated Water (CASRN 10599-90-3) (Deionized and Charcoal-Filtered) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1992 Long-Term Carcinogenicity
TR-391 PDF (11MB) Toxicology and Carcinogenesis Studies of Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1991 Long-Term Carcinogenicity
TR-390 PDF (12MB) Toxicology and Carcinogenesis Studies of 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82-8) in F344/N Rats (Drinking Water Studies) 1991 Long-Term Carcinogenicity
TR-389 PDF (8MB) Toxicology and Carcinogeneis Studies of Sodium Azide (CASRN 26628-22-8) in F344 Rats (Gavage Studies) 1991 Long-Term Carcinogenicity
TR-388 PDF (14MB) Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies) 1992 Long-Term Carcinogenicity
TR-387 PDF (10MB) Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1991 Long-Term Carcinogenicity
TR-386 PDF (13MB) Toxicology and Carcinogenesis Studies of Tetranitromethane (CASRN 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-385 PDF (7MB) Toxicology and Carcinogenesis Studies of Methyl Bromide (CASRN 74-83-9) in B6C3F1 Mice (Inhalation Studies) 1992 Long-Term Carcinogenicity
TR-384 PDF (5MB) Toxicology and Carcinogenesis Studies of 1,2,3-Trichloropropane (CASRN 96-18-4) in F344 Rats and B6C3F1 Mice (Feed Studies) 1993 Long-Term Carcinogenicity
TR-383 PDF (11MB) Toxicology and Carcinogenesis Studies of 1-Amino-2,4-Dibromoanthraquinone (CASRN 81-49-2) in F344 Rats and B6C3F1 Mice (Feed Studies) 1996 Long-Term Carcinogenicity
TR-382 PDF (12MB) Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-381 PDF (6MB) Toxicology and Carcinogenesis Studies of d-Carvone (CASRN 2244-16-8) in B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-380 PDF (22MB) Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CASRN 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-379 PDF (24MB) Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CASRN 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-378 PDF (14MB) Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-377 PDF (12MB) Toxicology and Carcinogenesis Studies of CS2 (94% o-Chlorobenzalmalononitrile, CASRN 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-376 PDF (14MB) Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-375 PDF (21MB) Toxicology and Carcinogenesis Studies of Vinyl Toluene (Mixed Isomers) (65%-71% meta-isomer and 32%-35% para-isomer) (CASRN 25013-15-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-374 PDF (12MB) Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-373 PDF (22MB) Toxicology and Carcinogenesis Studies of Succinic Anhydride (CASRN 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-372 PDF (13MB) Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies) 1990 Long-Term Carcinogenicity
TR-371 PDF (16MB) Toxicology and Carcinogenesis Studies of Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1990 Long-Term Carcinogenicity
TR-370 PDF (13MB) Toxicology and Carcinogenesis Studies of Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-369 PDF (16MB) Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-368 PDF (13MB) Toxicology and Carcinogenesis Studies of Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-367 PDF (11MB) Toxicology and Carcinogenesis Studies of Phenylbutazone (CASRN 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-366 PDF (14MB) Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-365 PDF (22MB) Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-364 PDF (11MB) Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-363 PDF (11MB) Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CASRN 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1989 Long-Term Carcinogenicity
TR-362 PDF (15MB) Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CASRN 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies) 1989 Long-Term Carcinogenicity
TR-361 PDF (7MB) Toxicology and Carcinogenesis Studies of Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-360 PDF (10MB) Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-359 PDF (8MB) Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-358 PDF (8MB) Toxicology and Carcinogenesis Studies of Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-357 PDF (12MB) Toxicology and Carcinogenesis Studies of Hydrochlorothiazide (CASRN 58-93-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-356 PDF (12MB) Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-355 PDF (11MB) Toxicology and Carcinogenesis Studies of Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-354 PDF (12MB) Toxicology and Carcinogenesis Studies of Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-353 PDF (10MB) Toxicology and Carcinogenesis Studies of 2,4-Dichlorophenol (CASRN 120-83-2) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-352 PDF (27MB) Toxicology and Carcinogenesis Studies of N-Methylolacrylamide (CASRN 924-42-5) in F344/N Rats and B6C3F1 Mice 1989 Long-Term Carcinogenicity
TR-351 PDF (12MB) Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-350 PDF (12MB) Toxicology and Carcinogenesis Studies of Tribromomethane (Bromoform) (CASRN 75-25-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-349 PDF (31MB) Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CASRN 87-86-5) in B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-348 PDF (11MB) Toxicology and Carcinogenesis Studies of alpha-Methyldopa Sesquihydrate (CASRN 41372-08-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-347 PDF (10MB) Toxicology and Carcinogenesis Studies of d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-346 PDF (9MB) Toxicology and Carcinogenesis Studies of Chloroethane (Ethyl Chloride) (CASRN 75-00-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1989 Long-Term Carcinogenicity
TR-345 PDF (25MB) Toxicology and Carcinogenesis Studies of Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-344 PDF (10MB) Toxicology and Carcinogenesis Studies of Tetracycline Hydrochloride (CASRN 64-75-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-343 PDF (9MB) Toxicology and Carcinogenesis Studies of Benzyl Alcohol (CASRN 100-51-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-342 PDF (30MB) Toxicology and Carcinogenesis Studies of Dichlorvos (CASRN 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term Carcinogenicity
TR-341 PDF (10MB) Toxicology and Carcinogenesis Studies of Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1989 Long-Term Carcinogenicity
TR-340 PDF (10MB) Toxicology and Carcinogenesis Studies of Iodinated Glycerol (Organidin®) (CASRN 5634-39-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-339 PDF (11MB) Toxicology and Carcinogenesis Studies of 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-338 PDF (10MB) Toxicology and Carcinogenesis Studies of Erythromycin Stearate (CASRN 643-22-1) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1988 Long-Term Carcinogenicity
TR-337 PDF (11MB) Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1988 Long-Term Carcinogenicity
TR-336 PDF (10MB) Toxicology and Carcinogenesis Studies of Penicillin VK (CASRN 132-98-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-335 PDF (12MB) Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-334 PDF (9MB) Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-333 PDF (9MB) Toxicology and Carcinogenesis Studies of N-Phenyl-2-Naphthylamine (CASRN 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1988 Long-Term Carcinogenicity
TR-332 PDF (10MB) Toxicology and Carcinogenesis Studies of 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-331 PDF (7MB) Toxicology and Carcinogenesis Studies of Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium Salt) (CASRN 24382-04-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-330 PDF (9MB) Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CASRN 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-329 PDF (10MB) Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1988 Long-Term Carcinogenicity
TR-328 PDF (10MB) Toxicology and Carcinogenesis Studies of Methyl Carbamate (CASRN 598-55-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-327 PDF (9MB) Toxicology and Carcinogenesis Studies of Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene, and 17% Ethylbenzene)(CASRN 1330-20-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-326 PDF (7MB) Toxicology and Carcinogenesis Studies of Ethylene Oxide (CASRN 75-21-8) in B6C3F1 Mice (Inhalation Studies) 1987 Long-Term Carcinogenicity
TR-325 PDF (7MB) Toxicology and Carcinogenesis Studies of Pentachloronitrobenzene (CASRN 82-68-8) in B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-324 PDF (7MB) Toxicology and Carcinogenesis Studies of Boric Acid (CASRN 10043-35-3) in B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-323 PDF (10MB) Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-322 PDF (11MB) Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CASRN 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-321 PDF (11MB) Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-320 PDF (12MB) Toxicology and Carcinogenesis Studies of Rotenone (CASRN 83-79-4) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1988 Long-Term Carcinogenicity
TR-319 PDF (18MB) Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-318 PDF (11MB) Toxicology and Carcinogenesis Studies of Ampicillin Trihydrate (CASRN 7177-48-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-317 PDF (11MB) Toxicology and Carcinogenesis Studies of Chlorpheniramine Maleate (CASRN 113-92-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-316 PDF (15MB) Toxicology and Carcinogenesis Studies of Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN 513-37-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-315 PDF (10MB) Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CASRN 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-314 PDF (11MB) Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1986 Long-Term Carcinogenicity
TR-313 PDF (14MB) Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta[cd]pentalene) (CASRN 2385-85-5) in F344/N Rats (Feed Studies) 1990 Long-Term Carcinogenicity
TR-312 PDF (15MB) Toxicology and Carcinogenesis Studies of n-Butyl Chloride (CASRN 109-69-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-311 PDF (14MB) Toxicology and Carcinogenesis Studies of Tetrachloroethylene (Perchloroethylene) (CASRN 127-18-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1986 Long-Term Carcinogenicity
TR-310 PDF (10MB) Toxicology and Carcinogenesis Studies of Marine Diesel Fuel and JP-5 Navy Fuel (CASRN 8008-20-6) in B6C3F1 Mice (Dermal Studies) 1986 Long-Term Carcinogenicity
TR-309 PDF (18MB) Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1986 Long-Term Carcinogenicity
TR-308 PDF (12MB) Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C12, 60% Chlorine) (CASRN 108171-26-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-307 PDF (12MB) Toxicology and Carcinogenesis Studies of Ephedrine Sulfate (CASRN 134-72-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1986 Long-Term Carcinogenicity
TR-306 PDF (14MB) Toxicology and Carcinogenesis Studies of Dichloromethane (Methylene Chloride) (CASRN 75-09-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1986 Long-Term Carcinogenicity
TR-305 PDF (13MB) Toxicology and Carcinogenesis Studies of Chlorinated Paraffins (C23, 43Chlorine) (CASRN 108171-27-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-304 PDF (15MB) Toxicology and Carcinogenesis Studies of Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-303 PDF (11MB) Toxicology and Carcinogenesis Studies of 4-Vinylcyclohexene (CASRN 100-40-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-302 N/A 1,2-Epoxyhexadecane (CASRN 7320-37-8) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-301 PDF (15MB) Toxicology and Carcinogenesis Studies of ORTHO-Phenylphenol (CASRN 90-43-7) Alone and with 7,12-Dimethylbenz(a)anthracene (CASRN 57-97-6) in Swiss CD-1 Mice (Dermal Studies) 1986 Long-Term Carcinogenicity
TR-300 PDF (10MB) Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% Dimethylvinyl chloride) (CASRN 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-299 PDF (15MB) Toxicology and Carcinogenesis Studies of C.I. Disperse Blue 1 (A commercial dye containing approximately 50% 1,4,5,8-tetraaminoanthraquinone, and 20% water) (CASRN 2475-45-8) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1986 Long-Term Carcinogenicity
TR-298 PDF (10MB) Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CASRN 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-297 N/A Benzyl Chloride (CASRN 100-44-7) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-296 PDF (16MB) Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1987 Long-Term Carcinogenicity
TR-295 PDF (25MB) Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CASRN 12001-29-5) in F344/N Rats (Feed Studies) 1985 Long-Term Carcinogenicity
TR-294 PDF (6MB) Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate (CASRN 56802-99-4) in B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-293 PDF (8MB) Toxicology and Carcinogenesis Studies of HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)] (CASRN 33229-34-4) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1985 Long-Term Carcinogenicity
TR-292 N/A Trichlorfon (CASRN 52-68-6) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-291 PDF (10MB) Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-290 N/A Castor Oil (CASRN 8001-79-4) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-289 PDF (16MB) Toxicology and Carcinogenesis Studies of Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-288 PDF (5MB) Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies) 1984 Long-Term Carcinogenicity
TR-287 PDF (10MB) Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-286 N/A Hamamelis Water (Witch Hazel) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-285 PDF (14MB) Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CASRN 569-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1986 Long-Term Carcinogenicity
TR-284 PDF (8MB) Toxicology and Carcinogenesis Studies of Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-283 N/A Pyridine (CASRN 110-86-1) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-282 PDF (9MB) Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-281 PDF (9MB) Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CASRN 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-280 PDF (10MB) Toxicology and Carcinogenesis Studies of Crocidolite Asbestos (CASRN 12001-28-4) In F344/N Rats (Feed Studies) 1988 Long-Term Carcinogenicity
TR-279 PDF (37MB) Toxicology and Carcinogenesis Studies of Amosite Asbestos (CASRN 12172-73-5) in F344/N Rats (Feed Studies) 1990 Long-Term Carcinogenicity
TR-278 PDF (9MB) Toxicology and Carcinogenesis Studies of 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in Charles River CD Rats (Feed Studies) 1990 Long-Term Carcinogenicity
TR-277 PDF (11MB) Toxicology and Carcinogenesis Studies of Tremolite (CASRN 14567-73-8) in F344/N Rats (Feed Studies) 1990 Long-Term Carcinogenicity
TR-276 PDF (9MB) Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CASRN 148-24-3) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1985 Long-Term Carcinogenicity
TR-275 PDF (14MB) Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07-3) in F344/N Rats and Swiss CD-1 Mice (Dermal Studies) 1985 Long-Term Carcinogenicity
TR-274 PDF (9MB) Toxicology and Carcinogenesis Studies of Tris(2-ethylhexyl)phosphate (CASRN 78-42-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1984 Long-Term Carcinogenicity
TR-273 PDF (17MB) Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies) 1988 Long-Term Carcinogenicity
TR-272 PDF (8MB) Toxicology and Carcinogenesis Studies of Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1985 Long-Term Carcinogenicity
TR-271 PDF (10MB) Toxicology and Carcinogenesis Studies of HC Blue No. 1 (CASRN 2784-94-3) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1985 Long-Term Carcinogenicity
TR-270 N/A Gilsonite (CASRN 12002-43-6) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-269 PDF (9MB) Toxicology and Carcinogenesis Studies of Telone® (Technical-Grade 1,3-Dichloropropane [CASRN 542-75-6] Containing 1.0 Epichlorohydrin as a Stabilizer) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-268 N/A Sodium Dodecyl Sulfate (CASRN 151-21-3) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-267 PDF (8MB) Toxicology and Carcinogenesis Studies of Propylene Oxide (CASRN 75-56-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1985 Long-Term Carcinogenicity
TR-266 PDF (12MB) Toxicology and Carcinogenesis Studies of Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1988 Long-Term Carcinogenicity
TR-265 N/A C.I. Acid Yellow 73 (Fluorescein Sodium) (CASRN 518-47-8) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-264 N/A Ethoxylated Dodecyl Alcohol (CASRN 9002-92-0) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-263 PDF (9MB) Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CASRN 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-262 N/A 1,1,1-Trichloroethane (Methyl Chloroform) (CASRN 71-55-6) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-261 PDF (11MB) Toxicology and Carcinogenesis Studies of Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-260 N/A Tetrachloroethylene (CASRN 127-18-4) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-259 PDF (12MB) Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-258 N/A DMBA(Dimethylbenzanthracene)/TPA(Tetradeca-noyl Phorbol) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-257 PDF (10MB) Toxicology and Carcinogenesis Studies of Diglycidyl Resorcinol Ether (Technical Grade) (CASRN 101-90-6) In F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-256 N/A Sodium (2-Ethylhexyl)Alcohol Sulfate (CASRN 126-92-1) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-255 PDF (8MB) Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1985 Long-Term Carcinogenicity
TR-254 N/A Dichloromethane (Methylene Chloride) (CASRN 75-09-2) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-253 PDF (11MB) Carcinogenesis Studies of Allyl Isovalerate (CASRN 2835-39-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1983 Long-Term Carcinogenicity
TR-252 PDF (6MB) Carcinogenesis Studies of Food Grade Geranyl Acetate (71% Geranyl Acetate, 29% Citronellyl Acetate) (CASRN 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study) 1987 Long-Term Carcinogenicity
TR-251 PDF (9MB) Toxicology and Carcinogenesis Studies of Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate (CASRN 26471-62-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-250 PDF (9MB) Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1986 Long-Term Carcinogenicity
TR-249 PDF (4MB) Lifetime Carcinogenesis Studies of Amosite Asbestos (CASRN 12172-73-5) in Syrian Golden Hamsters (Feed Studies) 1983 Long-Term Carcinogenicity
TR-248 PDF (10MB) Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1983 Long-Term Carcinogenicity
TR-247 PDF (8MB) Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study) 1983 Long-Term Carcinogenicity
TR-246 PDF (10MB) Lifetime Carcinogenesis Studies of Chrysotile Asbestos (CASRN 12001-29-5) in Syrian Golden Hamsters (Feed Studies) 1990 Long-Term Carcinogenicity
TR-245 PDF (8MB) Carcinogenesis Bioassay of Melamine (CASRN 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study) 1983 Long-Term Carcinogenicity
TR-244 PDF (9MB) Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1983 Long-Term Carcinogenicity
TR-243 PDF (8MB) Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term Carcinogenicity
TR-242 PDF (4MB) Carcinogenesis Bioassay of Diallyl Phthalate (CASRN 131-17-9) in B6C3F1 Mice (Gavage Study) 1983 Long-Term Carcinogenicity
TR-241 N/A Proceedings of a Working Seminar on the Optimal Use of Facilities for Carcinogenicity/Toxicity Testing - No technical report prepared. N/A Long-Term Carcinogenicity
TR-240 PDF (7MB) Carcinogenesis Bioassay of Propyl Gallate (CASRN 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-239 PDF (4MB) Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CASRN 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CASRN 83270-31-9) in B6C3F1 Mice (Gavage Study) 1982 Long-Term Carcinogenicity
TR-238 PDF (11MB) Carcinogenesis Bioassay of Ziram (CASRN 137-30-4) in F344/N Rats and B6C3F1 Mice (Feed Study) 1983 Long-Term Carcinogenicity
TR-237 PDF (6MB) Carcinogenesis Studies of 1,1,1,2-Tetrachloroethane (CASRN 630-20-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1983 Long-Term Carcinogenicity
TR-236 PDF (6MB) Carcinogenesis Bioassay of D-Mannitol (CASRN 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-235 PDF (7MB) Carcinogenesis Bioassay of Zearalenone (CASRN 17924-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-234 PDF (11MB) Carcinogenesis Bioassay of Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study) 1982 Long-Term Carcinogenicity
TR-233 PDF (8MB) Carcinogenesis Bioassay of 2-Biphenylamine Hydrochloride (CASRN 2185-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-232 PDF (7MB) Carcinogenesis Studies of Pentachloroethane (CASRN 76-01-7) in F344/N Rats and B6C3F1 Mice (Gavage Study) 1983 Long-Term Carcinogenicity
TR-231 PDF (8MB) Carcinogenesis Bioassay of Stannous Chloride (CASRN 7772-99-8) in F344/N Rats and B6C3F1/N Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-230 PDF (4MB) Carcinogenesis Bioassay of Agar (CASRN 9002-18-0) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-229 PDF (4MB) Carcinogenesis Bioassay of Guar Gum (CASRN 9000-30-0) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-228 PDF (8MB) Carcinogenesis Bioassay of Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and B6C3F1 Mice (Gavage Study) 1982 Long-Term Carcinogenicity
TR-227 PDF (4MB) Carcinogenesis Bioassay of Gum Arabic (CASRN 9000-01-5) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-226 PDF (7MB) Carcinogenesis Bioassay of C.I. Solvent Yellow 14 (CASRN 842-07-9) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-225 PDF (7MB) Carcinogenesis Bioassay of D & C Red No. 9 (CASRN 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-224 PDF (4MB) Carcinogenesis Bioassay of Tara Gum (CASRN 39300-88-4) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-223 PDF (7MB) Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) 1983 Long-Term Carcinogenicity
TR-222 PDF (7MB) Carcinogenesis Bioassay of Disperse Yellow 3 (CASRN 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-221 PDF (3MB) Carcinogenesis Bioassay of Locust Bean Gum (CASRN 9000-40-2) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-220 PDF (4MB) Carcinogenesis Bioassay of C.I. Acid Red 14 (CASRN 3567-69-9) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-219 PDF (4MB) Carcinogenesis Bioassay of 2,6-Dichloro-p-Phenylenediamine (CASRN 609-20-1) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-218 PDF (3MB) Monitoring Guidelines for the Conduct of Carcinogen Bioassays 1981 Long-Term Carcinogenicity
TR-217 PDF (5MB) Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies) 1982 Long-Term Carcinogenicity
TR-216 PDF (8MB) Carcinogenesis Bioassay of 11-Aminoundecanoic Acid (CASRN 2432-99-7) in F344 Rats and B6C3F1 Mice 1982 Long-Term Carcinogenicity
TR-215 PDF (4MB) Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-214 PDF (4MB) Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-213 PDF (4MB) Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-212 PDF (4MB) Carcinogenesis Bioassay of Di(2-ethylhexyl)adipate (CASRN 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity
TR-211 PDF (7MB) Carcinogenesis Studies of C.I. Acid Orange 10 (CASRN 1936-15-8) in F344 Rats and B6C3F1 Mice (Feed Studies) 1987 Long-Term Carcinogenicity
TR-210 PDF (7MB) Carcinogenesis Bioassay of 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study) 1982 Long-Term Carcinogenicity
TR-209 PDF (8MB) Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study) 1982 Long-Term Carcinogenicity
TR-208 PDF (6MB) Carcinogenesis Bioassay of FD & C Yellow No. 6 (CASRN 2783-94-0) 1981 Long-Term Carcinogenicity
TR-207 PDF (4MB) Carcinogenesis Bioassay of Cytembena (CASRN 21739-91-3) 1981 Long-Term Carcinogenicity
TR-206 PDF (7MB) Carcinogenesis Bioassay of 1,2-Dibromo-3-chloropropane (CASRN 96-12-8) in F344 Rats and B6C3F1 Mice (Inhalation Study) 1982 Long-Term Carcinogenicity
TR-205 PDF (4MB) Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4) 1980 Long-Term Carcinogenicity
TR-204 PDF (4MB) Bioassay of Benzoin for Possible Carcinogenicity (CASRN119-53-9) 1980 Long-Term Carcinogenicity
TR-203 PDF (4MB) Bioassay of Phenol for Possible Carcinogenicity (CASRN108-95-2) 1980 Long-Term Carcinogenicity
TR-202 PDF (4MB) Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CASRN 57653-85-7; CASRN 19408-74-3) 1980 Long-Term Carcinogenicity
TR-201 PDF (5MB) Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice (Dermal Study) 1982 Long-Term Carcinogenicity
TR-200 PDF (4MB) Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 15481-70-6) 1980 Long-Term Carcinogenicity
TR-199 PDF (2MB) Bioassay of Selsun® for Possible Carcinogenicity 1980 Long-Term Carcinogenicity
TR-198 PDF (7MB) Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CASRN 57653-85-7, CASRN 19408-74-3) 1980 Long-Term Carcinogenicity
TR-197 PDF (2MB) Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CASRN 7446-34-6) 1980 Long-Term Carcinogenicity
TR-196 PDF (3MB) Bioassay of Cinnamyl Anthranilate for Possible Carcinogenicity (CASRN 87-29-6) 1980 Long-Term Carcinogenicity
TR-195 PDF (3MB) Bioassay of Fluometuron for Possible Carcinogenicity (CASRN 2164-17-2) 1980 Long-Term Carcinogenicity
TR-194 PDF (5MB) Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CASRN 7446-34-6) 1980 Long-Term Carcinogenicity
TR-193 PDF (3MB) Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) 1982 Long-Term Carcinogenicity
TR-192 PDF (2MB) Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5) 1979 Long-Term Carcinogenicity
TR-191 PDF (3MB) Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CASRN 108-60-1) 1979 Long-Term Carcinogenicity
TR-190 PDF (3MB) Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CASRN 156-10-5) 1979 Long-Term Carcinogenicity
TR-189 PDF (3MB) Bioassay of p-Chloroaniline for Possible Carcinogenicity (CASRN 106-47-8) 1979 Long-Term Carcinogenicity
TR-188 N/A Sodium Iodomethanesulfonate (CASRN 126-31-8) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-187 PDF (3MB) Bioassay of 5-Chloro-o-toluidine for Possible Carcinogenicity (CASRN 95-79-4) 1979 Long-Term Carcinogenicity
TR-186 PDF (5MB) Bioassay of 4,4'-Methylenebis-(N,N-dimethyl)benzeneamine for Possible Carcinogenicity (CASRN 101-61-1) 1979 Long-Term Carcinogenicity
TR-185 PDF (3MB) Bioassay of Styrene for Possible Carcinogenicity (CASRN100-42-5) 1979 Long-Term Carcinogenicity
TR-184 PDF (5MB) Bioassay of Nitrofen for Possible Carcinogenicity (CASRN 1836-75-5) 1979 Long-Term Carcinogenicity
TR-183 PDF (3MB) Bioassay of Dibutyltin Diacetate for Possible Carcinogenicity (CASRN 1067-33-0) 1979 Long-Term Carcinogenicity
TR-182 N/A Acetamide (CASRN 60-35-5) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-181 PDF (4MB) Bioassay of Michler's Ketone for Possible Carcinogenicity (CASRN 90-94-8) 1979 Long-Term Carcinogenicity
TR-180 PDF (3MB) Bioassay of 4-Nitro-o-phenylenediamine for Possible Carcinogenicity (CASRN 99-56-9) 1979 Long-Term Carcinogenicity
TR-179 PDF (3MB) Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CASRN 105-11-3) 1979 Long-Term Carcinogenicity
TR-178 PDF (3MB) Bioassay of 2-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CASRN 6959-47-3) 1979 Long-Term Carcinogenicity
TR-177 PDF (3MB) Bioassay of 4'-(Chloroacetyl)-acetanilide for Possible Carcinogenicity (CASRN 140-49-8) 1979 Long-Term Carcinogenicity
TR-176 N/A N,N-Dimethyl-P-Nitrosoaniline (CASRN 138-89-6) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-175 PDF (3MB) Bioassay of Lithocholic Acid for Possible Carcinogenicity (CASRN 434-13-9) 1979 Long-Term Carcinogenicity
TR-174 PDF (3MB) Bioassay of p-Phenylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 624-18-0) 1979 Long-Term Carcinogenicity
TR-173 PDF (3MB) Bioassay of Carbromal for Possible Carcinogenicity (CASRN 77-65-6) 1979 Long-Term Carcinogenicity
TR-172 PDF (5MB) Bioassay of Sodium Diethyldithiocarbamate for Possible Carcinogenicity (CASRN 148-18-5) 1979 Long-Term Carcinogenicity
TR-171 PDF (3MB) Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CASRN 54150-69-5) 1979 Long-Term Carcinogenicity
TR-170 PDF (5MB) Bioassay of a Solution of ß-Nitrostyrene and Styrene for Possible Carcinogenicity (CASRN 102-96-5, CASRN 100-42-5) 1979 Long-Term Carcinogenicity
TR-169 PDF (3MB) Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2) 1979 Long-Term Carcinogenicity
TR-168 PDF (5MB) Bioassay of N-(1-Naphthyl)ethylenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 1465-25-4) 1979 Long-Term Carcinogenicity
TR-167 N/A N-Butylurea (CASRN 592-31-4) Sodium Nitrite (CASRN 7632-00-0) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-166 PDF (3MB) Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CASRN 97-77-8) 1979 Long-Term Carcinogenicity
TR-165 PDF (4MB) Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CASRN 3165-93-3) 1979 Long-Term Carcinogenicity
TR-164 PDF (6MB) Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (CASRN 86-30-6) 1979 Long-Term Carcinogenicity
TR-163 PDF (4MB) Bioassay of Calcium Cyanamide for Possible Carcinogenicity (CASRN 156-62-7) 1979 Long-Term Carcinogenicity
TR-162 PDF (4MB) Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7) 1979 Long-Term Carcinogenicity
TR-161 PDF (3MB) Bioassay of Phthalamide for Possible Carcinogenicity (CASRN 88-96-0) 1979 Long-Term Carcinogenicity
TR-160 PDF (3MB) Bioassay of 2,4,5-Trimethylaniline for Possible Carcinogenicity (CASRN 137-17-7) 1979 Long-Term Carcinogenicity
TR-159 PDF (4MB) Bioassay of Phthalic Anhydride for Possible Carcinogenicity (CASRN 85-44-9) 1979 Long-Term Carcinogenicity
TR-158 PDF (3MB) Bioassay of (2-Chloroethyl)trimethylammonium Chloride (CCC) for Possible Carcinogenicity (CASRN 999-81-5) 1979 Long-Term Carcinogenicity
TR-157 PDF (4MB) Bioassay of Methyl Parathion for Possible Carcinogenicity (CASRN 298-00-0) 1979 Long-Term Carcinogenicity
TR-156 PDF (4MB) Bioassay of p, p'-Ethyl-DDD for Possible Carcinogenicity (CASRN 72-56-0) 1979 Long-Term Carcinogenicity
TR-155 PDF (3MB) Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity (CASRN 88-06-2) 1979 Long-Term Carcinogenicity
TR-154 PDF (4MB) Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3) 1979 Long-Term Carcinogenicity
TR-153 PDF (2MB) Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5) 1979 Long-Term Carcinogenicity
TR-152 PDF (3MB) Bioassay of Ethyl Tellurac for Possible Carcinogenicity (CASRN 20941-65-5) 1979 Long-Term Carcinogenicity
TR-151 PDF (3MB) Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CASRN 19010-66-3) 1979 Long-Term Carcinogenicity
TR-150 PDF (4MB) Bioassay of Butylated Hydroxytoluene (BHT) for Possible Carcinogenicity (CASRN 128-37-0) 1979 Long-Term Carcinogenicity
TR-149 PDF (3MB) Bioassay of N,N'-Diethylthiourea for Possible Carcinogenicity (CASRN 105-55-5) 1979 Long-Term Carcinogenicity
TR-148 PDF (3MB) Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CASRN 103-85-5) 1978 Long-Term Carcinogenicity
TR-147 PDF (3MB) Bioassay of Mexacarbate for Possible Carcinogenicity (CASRN 315-18-4) 1978 Long-Term Carcinogenicity
TR-146 PDF (3MB) Bioassay of Nithiazide for Possible Carcinogenicity (CASRN 139-94-6) 1979 Long-Term Carcinogenicity
TR-145 PDF (3MB) Bioassay of 3-Chloro-p-Toluidine for Possible Carcinogenicity (CASRN 95-74-9) 1978 Long-Term Carcinogenicity
TR-144 PDF (4MB) Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CASRN 117-79-3) 1978 Long-Term Carcinogenicity
TR-143 PDF (4MB) Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CASRN 2243-62-1) 1978 Long-Term Carcinogenicity
TR-142 PDF (3MB) Bioassay of p-Cresidine for Possible Carcinogenicity (CASRN 120-71-8) 1979 Long-Term Carcinogenicity
TR-141 PDF (3MB) Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CASRN 89-25-8) 1978 Long-Term Carcinogenicity
TR-140 PDF (3MB) Bioassay of Pivalolactone for Possible Carcinogenicity (CASRN 1955-45-9) 1978 Long-Term Carcinogenicity
TR-139 PDF (3MB) Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity (CASRN 76-87-9) 1978 Long-Term Carcinogenicity
TR-138 PDF (4MB) Bioassay of Sulfisoxazole for Possible Carcinogenicity (CASRN 127-69-5) 1979 Long-Term Carcinogenicity
TR-137 PDF (3MB) Bioassay of Diazinon for Possible Carcinogenicity (CASRN 333-41-5) 1979 Long-Term Carcinogenicity
TR-136 PDF (3MB) Bioassay of Aldicarb for Possible Carcinogenicity (CASRN 116-06-3) 1979 Long-Term Carcinogenicity
TR-135 PDF (3MB) Bioassay of Malaoxon for Possible Carcinogenicity (CASRN 1634-78-2) 1979 Long-Term Carcinogenicity
TR-134 PDF (3MB) Bioassay of C.I. Vat Yellow 4 for Possible Carcinogenicity (CASRN 128-66-5) 1979 Long-Term Carcinogenicity
TR-133 PDF (3MB) Bioassay of 3-Nitro-p-Acetophenetide for Possible Carcinogenicity (CASRN 1777-84-0) 1979 Long-Term Carcinogenicity
TR-132 PDF (3MB) Bioassay of 2,5-Dithiobiurea for Possible Carcinogenicity (CASRN 142-46-1) 1979 Long-Term Carcinogenicity
TR-131 PDF (8MB) Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN 72-54-8, CASRN 72-55-9) 1978 Long-Term Carcinogenicity
TR-130 PDF (4MB) Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN 142-04-1) 1978 Long-Term Carcinogenicity
TR-129 PDF (3MB) Bioassay of Trimethylthiourea for Possible Carcinogenicity (CASRN 2489-77-2) 1979 Long-Term Carcinogenicity
TR-128 PDF (4MB) Bioassay of 3,3'-Dimethoxybenzidine-4,4'-diisocyanate for Possible Carcinogenicity (CASRN 91-93-0) 1979 Long-Term Carcinogenicity
TR-127 PDF (5MB) Bioassay of 5-Nitro-o-anisidine for Possible Carcinogenicity (CASRN 99-59-2) 1978 Long-Term Carcinogenicity
TR-126 PDF (4MB) Bioassay of 2,5-Toluenediamine Sulfate for Possible Carcinogenicity (CASRN 6369-59-1) 1978 Long-Term Carcinogenicity
TR-125 PDF (2MB) Bioassay of Dioxathion for Possible Carcinogenicity (CASRN 78-34-2) 1978 Long-Term Carcinogenicity
TR-124 PDF (4MB) Bioassay of Piperonyl Sulfoxide for Possible Carcinogenicity (CASRN 120-62-7) 1979 Long-Term Carcinogenicity
TR-123 PDF (3MB) Bioassay of 2,7-Dichlorodibenzo-p-dioxin (DCDD) for Possible Carcinogenicity (CASRN 33857-26-0) 1979 Long-Term Carcinogenicity
TR-122 PDF (3MB) Bioassay of Dibenzo-p-dioxin for Possible Carcinogenicity (CASRN 262-12-4) 1979 Long-Term Carcinogenicity
TR-121 PDF (4MB) Bioassay of Dimethyl Terephthalate for Possible Carcinogenicity (CASRN 120-61-6) 1979 Long-Term Carcinogenicity
TR-120 PDF (4MB) Bioassay of Piperonyl Butoxide for Possible Carcinogenicity (CASRN 51-03-6) 1979 Long-Term Carcinogenicity
TR-119 N/A Carbon Disulfide (CASRN 75-15-0) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-118 PDF (4MB) Bioassay of 5-Nitroacenaphthene for Possible Carcinogenicity (CASRN 602-87-9) 1978 Long-Term Carcinogenicity
TR-117 PDF (4MB) Bioassay of 6-Nitrobenzimidazole for Possible Carcinogenicity (CASRN 94-52-0) 1979 Long-Term Carcinogenicity
TR-116 PDF (3MB) Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 20265-97-8) 1978 Long-Term Carcinogenicity
TR-115 PDF (4MB) Bioassay of Sulfallate for Possible Carcinogenicity (CASRN 95-06-7) 1978 Long-Term Carcinogenicity
TR-114 PDF (4MB) Bioassay of 2,3,5,6-Tetrachloro-4-nitroanisole for Possible Carcinogenicity (CASRN 2438-88-2) 1978 Long-Term Carcinogenicity
TR-113 PDF (3MB) Bioassay of 2-Chloro-p-phenylenediamine Sulfate for Possible Carcinogenicity (CASRN 61702-44-1) 1978 Long-Term Carcinogenicity
TR-112 PDF (4MB) Bioassay of 3-Amino-4-ethoxyacetanilide for Possible Carcinogenicity (CASRN 17026-81-2) 1978 Long-Term Carcinogenicity
TR-111 PDF (4MB) Bioassay of 1-Amino-2-methylanthraquinone for Possible Carcinogenicity (CASRN 82-28-0) 1978 Long-Term Carcinogenicity
TR-110 PDF (3MB) Bioassay of Iodoform for Possible Carcinogenicity (CASRN 75-47-8) 1978 Long-Term Carcinogenicity
TR-109 PDF (4MB) Bioassay of 4-Nitroanthranilic Acid for Possible Carcinogenicity (CASRN 619-17-0) 1978 Long-Term Carcinogenicity
TR-108 PDF (4MB) 13-Week Subchronic Toxicity Studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 Dyes 1978 Long-Term Carcinogenicity
TR-107 PDF (3MB) Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (CASRN 99-55-8) 1978 Long-Term Carcinogenicity
TR-106 PDF (3MB) Bioassay of Trichlorofluoromethane for Possible Carcinogenicity (CASRN 75-69-4) 1978 Long-Term Carcinogenicity
TR-105 PDF (4MB) Bioassay of m-Cresidine for Possible Carcinogenicity (CASRN 102-50-1) 1978 Long-Term Carcinogenicity
TR-104 PDF (3MB) Bioassay of Anilazine for Possible Carcinogenicity (CASRN 101-05-3) 1978 Long-Term Carcinogenicity
TR-103 PDF (3MB) Bioassay of Fenthion for Possible Carcinogenicity (CASRN 55-38-9) 1979 Long-Term Carcinogenicity
TR-102 PDF (4MB) Bioassay of 3-Sulfolene for Possible Carcinogenicity (CASRN 77-79-2) 1978 Long-Term Carcinogenicity
TR-101 PDF (3MB) Bioassay of Formulated Fenaminosulf for Possible Carcinogenicity (CASRN 140-56-7) 1978 Long-Term Carcinogenicity
TR-100 PDF (4MB) Bioassay of Cupferron for Possible Carcinogenicity (CASRN 135-20-6) 1978 Long-Term Carcinogenicity
TR-099 PDF (3MB) Bioassay of Phenazopyridine Hydrochloride for Possible Carcinogenicity (CASRN 136-40-3) 1978 Long-Term Carcinogenicity
TR-098 PDF (4MB) Bioassay of dl-Menthol for Possible Carcinogenicity (CASRN 89-78-1) 1979 Long-Term Carcinogenicity
TR-097 PDF (4MB) Bioassay of Titanium Dioxide for Possible Carcinogenicity (CASRN 13463-67-7) 1979 Long-Term Carcinogenicity
TR-096 PDF (3MB) Bioassay of Coumaphos for Possible Carcinogenicity (CASRN 56-72-4) 1979 Long-Term Carcinogenicity
TR-095 PDF (4MB) Bioassay of 3-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CASRN 6959-48-4) 1978 Long-Term Carcinogenicity
TR-094 PDF (3MB) Bioassay of 4-Amino-2-nitrophenol for Possible Carcinogenicity (CASRN 119-34-6) 1978 Long-Term Carcinogenicity
TR-093 PDF (6MB) Bioassay of 3-Amino-9-ethylcarbazole Hydrochloride for Possible Carcinogenicity (CASRN 132-32-1) 1978 Long-Term Carcinogenicity
TR-092 PDF (4MB) Bioassay of Hydrazobenzene for Possible Carcinogenicity (CASRN 122-66-7) 1978 Long-Term Carcinogenicity
TR-091 PDF (3MB) Bioassay of Clonitralid for Possible Carcinogenicity (CASRN 1420-04-8) 1978 Long-Term Carcinogenicity
TR-090 PDF (3MB) Bioassay of Dicofol for Possible Carcinogenicity (CASRN 115-32-2) 1978 Long-Term Carcinogenicity
TR-089 PDF (4MB) Bioassay of o-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 134-29-2) 1978 Long-Term Carcinogenicity
TR-088 PDF (3MB) Bioassay of 1H-Benzotriazole for Possible Carcinogenicity (CASRN 95-14-7) 1978 Long-Term Carcinogenicity
TR-087 N/A 1,3-Dichloro-5,5-Dimethylhydantoin (CASRN 118-52-5) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-086 PDF (4MB) Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CASRN 106-93-4) 1978 Long-Term Carcinogenicity
TR-085 PDF (3MB) Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CASRN 5131-60-2) 1978 Long-Term Carcinogenicity
TR-084 PDF (5MB) Bioassay of 2,4-Diaminoanisole Sulfate for Possible Carcinogenicity (CASRN 615-05-4) 1978 Long-Term Carcinogenicity
TR-083 PDF (4MB) Bioassay of Daminozide for Possible Carcinogenicity (CASRN 1596-84-5) 1978 Long-Term Carcinogenicity
TR-082 PDF (3MB) Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CASRN 101-54-2) 1978 Long-Term Carcinogenicity
TR-081 PDF (3MB) Bioassay of Trimethylphosphate for Possible Carcinogenicity (CASRN 512-56-1) 1978 Long-Term Carcinogenicity
TR-080 PDF (3MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Long-Term Carcinogenicity
TR-079 N/A Dulcin (CAS: 150-69-6) - No technical report prepared. N/A Long-Term Carcinogenicity
TR-078 PDF (3MB) Bioassay of ICRF-159 for Possible Carcinogenicity (CASRN 21416-87-5) 1978 Long-Term Carcinogenicity
TR-077 PDF (3MB) Bioassay of Pyrimethamine for Possible Carcinogenicity (CASRN 58-14-0) 1978 Long-Term Carcinogenicity
TR-076 PDF (4MB) Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CASRN 126-72-7) 1978 Long-Term Carcinogenicity
TR-075 PDF (3MB) Bioassay of Chlorobenzilate for Possible Carcinogenicity (CASRN 510-15-6) 1978 Long-Term Carcinogenicity
TR-074 PDF (3MB) Bioassay of 1,1,2-Trichloroethane for Possible Carcinogenicity (CASRN 79-00-5) 1978 Long-Term Carcinogenicity
TR-073 PDF (4MB) Bioassay of Allyl Chloride for Possible Carcinogenicity (CASRN 107-05-1) 1978 Long-Term Carcinogenicity
TR-072 PDF (3MB) Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity (CASRN 63-92-3) 1978 Long-Term Carcinogenicity
TR-071 PDF (3MB) Bioassay of L-Tryptophan for Possible Carcinogenicity (CASRN 73-22-3) 1978 Long-Term Carcinogenicity
TR-070 PDF (3MB) Bioassay of Parathion for Possible Carcinogenicity (CASRN 56-38-2) 1979 Long-Term Carcinogenicity
TR-069 PDF (4MB) Bioassay of Azinphosmethyl for Possible Carcinogenicity (CASRN 86-50-0) 1978 Long-Term Carcinogenicity
TR-068 PDF (3MB) Bioassay of Hexachloroethane for Possible Carcinogenicity (CASRN 67-72-1) 1978 Long-Term Carcinogenicity
TR-067 PDF (3MB) Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity (CASRN 8003-03-0) 1978 Long-Term Carcinogenicity
TR-066 PDF (3MB) Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CASRN 75-34-3) 1978 Long-Term Carcinogenicity
TR-065 PDF (3MB) Bioassay of Chloropicrin for Possible Carcinogenicity (CASRN 76-06-2) 1978 Long-Term Carcinogenicity
TR-064 PDF (4MB) Bioassay of 1-Nitronaphthalene for Possible Carcinogenicity (CASRN 86-57-7) 1978 Long-Term Carcinogenicity
TR-063 PDF (3MB) Bioassay of 4-Chloro-o-phenylenediamine for Possible Carcinogenicity (CASRN 95-83-0) 1978 Long-Term Carcinogenicity
TR-062 PDF (3MB) Bioassay of Endosulfan for Possible Carcinogenicity (CASRN 115-29-7) 1978 Long-Term Carcinogenicity
TR-061 PDF (3MB) Bioassay of Pentachloronitrobenzene for Possible Carcinogenicity (CASRN 82-68-8) 1978 Long-Term Carcinogenicity
TR-060 PDF (4MB) Bioassay of Phenesterin for Possible Carcinogenicity (CASRN 3546-10-9) 1978 Long-Term Carcinogenicity
TR-059 PDF (4MB) Bioassay of Estradiol Mustard for Possible Carcinogenicity (CASRN 22966-79-6) 1978 Long-Term Carcinogenicity
TR-058 PDF (5MB) Bioassay of Thio-TEPA for Possible Carcinogenicity (CASRN 52-24-4) 1978 Long-Term Carcinogenicity
TR-057 PDF (4MB) Bioassay of ß-TGdR for Possible Carcinogenicity (CASRN 789-61-7) 1978 Long-Term Carcinogenicity
TR-056 PDF (4MB) Bioassay of N,N'-Dicyclohexylthiourea for Possible Carcinogenicity (CASRN 1212-29-9) 1978 Long-Term Carcinogenicity
TR-055 PDF (4MB) Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2) 1978 Long-Term Carcinogenicity
TR-054 PDF (4MB) Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN 121-14-2) 1978 Long-Term Carcinogenicity
TR-053 PDF (4MB) Bioassay of 2-Amino-5-Nitrothiazole for Possible Carcinogenicity (CASRN 121-66-4) 1978 Long-Term Carcinogenicity
TR-052 PDF (4MB) Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CASRN 504-88-1) 1978 Long-Term Carcinogenicity
TR-051 PDF (3MB) Bioassay of Tolazamide for Possible Carcinogenicity (CASRN 1156-19-0) 1978 Long-Term Carcinogenicity
TR-050 PDF (3MB) Bioassay of Acetohexamide for Possible Carcinogenicity (CASRN 968-81-0) 1978 Long-Term Carcinogenicity
TR-049 PDF (5MB) Bioassay of Acronycine for Possible Carcinogenicity (CASRN 7008-42-6) 1978 Long-Term Carcinogenicity
TR-048 PDF (3MB) Bioassay of Pyrazinamide for Possible Carcinogenicity (CASRN 98-96-4) 1978 Long-Term Carcinogenicity
TR-047 PDF (3MB) Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity (CASRN 139-65-1) 1978 Long-Term Carcinogenicity
TR-046 PDF (3MB) Bioassay of Ethionamide for Possible Carcinogenicity (CASRN 536-33-4) 1978 Long-Term Carcinogenicity
TR-045 PDF (2MB) Bioassay of Chlorpropamide for Possible Carcinogenicity (CASRN 94-20-2) 1978 Long-Term Carcinogenicity
TR-044 PDF (19MB) In Vitro Carcinogenisis: Guide to the Literature, Recent Advances and Laboratory Procedures (1978) 1978 Long-Term Carcinogenicity
TR-043 PDF (4MB) Bioassay of Emetine for Possible Carcinogenicity (CASRN 483-18-1) 1978 Long-Term Carcinogenicity
TR-042 PDF (3MB) Bioassay of 5-Azacytidine for Possible Carcinogenicity (CASRN 320-67-2) 1978 Long-Term Carcinogenicity
TR-041 PDF (3MB) Bioassay of Chlorothalonil for Possible Carcinogenicity (CASRN 1897-45-6) 1978 Long-Term Carcinogenicity
TR-040 PDF (2MB) Bioassay of Hexachlorophene for Possible Carcinogenicity (CASRN 70-30-4) 1978 Long-Term Carcinogenicity
TR-039 PDF (2MB) Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4) 1978 Long-Term Carcinogenicity
TR-038 PDF (1MB) Bioassay of Aroclor® for Possible Carcinogenicity (CASRN 27323-18-8) 1978 Long-Term Carcinogenicity
TR-037 PDF (3MB) Bioassay of Toxaphene for Possible Carcinogenicity (CASRN 8001-35-2) 1979 Long-Term Carcinogenicity
TR-036 PDF (3MB) Bioassay of Anthranilic Acid for Possible Carcinogenicity (CASRN 118-92-3) 1978 Long-Term Carcinogenicity
TR-035 PDF (3MB) Bioassay of Methoxychlor for Possible Carcinogenicity (CASRN 72-43-5) 1978 Long-Term Carcinogenicity
TR-034 PDF (4MB) Bioassay of Trifluralin for Possible Carcinogenicity (CASRN 1582-09-8) 1978 Long-Term Carcinogenicity
TR-033 PDF (4MB) Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CASRN 961-11-5) 1978 Long-Term Carcinogenicity
TR-032 PDF (4MB) Bioassay of Isophosphamide for Possible Carcinogenicity (CASRN 3778-73-2) 1977 Long-Term Carcinogenicity
TR-031 PDF (2MB) Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7) 1977 Long-Term Carcinogenicity
TR-030 PDF (3MB) Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CASRN 6358-85-6) 1978 Long-Term Carcinogenicity
TR-029 PDF (3MB) Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CASRN 129-15-7) 1978 Long-Term Carcinogenicity
TR-028 PDF (3MB) Bioassay of Dibromochloropropane for Possible Carcinogenicity (CASRN 96-12-8) 1978 Long-Term Carcinogenicity
TR-027 PDF (3MB) Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5) 1978 Long-Term Carcinogenicity
TR-026 PDF (3MB) Bioassay of Nitrofen for Possible Carcinogenicity (CASRN 1836-75-5) 1978 Long-Term Carcinogenicity
TR-025 PDF (3MB) Bioassay of Chloramben for Possible Carcinogenicity (CASRN 133-90-4) 1977 Long-Term Carcinogenicity
TR-024 PDF (3MB) Bioassay of Malathion for Possible Carcinogenicity (CASRN 121-75-5) 1978 Long-Term Carcinogenicity
TR-023 PDF (3MB) Bioassay of Picloram for Possible Carcinogenicity (CASRN 1918-02-1) 1978 Long-Term Carcinogenicity
TR-022 PDF (1MB) Bioassay of Dieldrin for Possible Carcinogenicity (CASRN 60-57-1) 1978 Long-Term Carcinogenicity
TR-021 PDF (5MB) Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) 1978 Long-Term Carcinogenicity
TR-020 PDF (3MB) Bioassay of Dapsone for Possible Carcinogenicity (CASRN 80-08-0) 1977 Long-Term Carcinogenicity
TR-019 PDF (3MB) Bioassay of Procarbazine for Possible Carcinogenicity (CASRN 366-70-1) 1979 Long-Term Carcinogenicity
TR-018 PDF (3MB) Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CASRN 3458-22-8) 1978 Long-Term Carcinogenicity
TR-017 PDF (3MB) Bioassay of Photodieldrin for Possible Carcinogenicity (CASRN 13366-73-9) 1977 Long-Term Carcinogenicity
TR-016 PDF (3MB) Bioassay of Phosphamidon for Possible Carcinogenicity (CASRN 13171-21-6) 1979 Long-Term Carcinogenicity
TR-015 PDF (3MB) Bioassay of Captan for Possible Carcinogenicity (CASRN 133-06-2) 1977 Long-Term Carcinogenicity
TR-014 PDF (3MB) Bioassay of Lindane for Possible Carcinogenicity (CASRN 58-89-9) 1977 Long-Term Carcinogenicity
TR-013 PDF (4MB) Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4) 1977 Long-Term Carcinogenicity
TR-012 PDF (3MB) Bioassay of Endrin for Possible Carcinogenicity (CASRN 72-20-8) 1979 Long-Term Carcinogenicity
TR-011 PDF (2MB) Bioassay of Trisodium Ethylenediaminetetraacetate Trihydrate (EDTA) for Possible Carcinogenicity (CASRN 150-38-9) 1977 Long-Term Carcinogenicity
TR-010 PDF (3MB) Bioassay of Dichlorvos for Possible Carcinogenicity (CASRN 62-73-7) 1977 Long-Term Carcinogenicity
TR-009 PDF (4MB) Bioassay of Heptachlor for Possible Carcinogenicity (CASRN 76-44-8) 1977 Long-Term Carcinogenicity
TR-008 PDF (4MB) Bioassay of Chlordane for Possible Carcinogenicity (CASRN 57-74-9) 1977 Long-Term Carcinogenicity
TR-007 PDF (4MB) Bioassay of Phenformin for Possible Carcinogenicity (CASRN 114-86-3) 1977 Long-Term Carcinogenicity
TR-006 PDF (5MB) Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O) 1977 Long-Term Carcinogenicity
TR-005 PDF (3MB) Bioassay of Proflavine for Possible Carcinogenicity (CASRN 952-23-8) 1977 Long-Term Carcinogenicity
TR-004 PDF (2MB) Bioassay of Dimethoate for Possible Carcinogenicity (CASRN 60-51-5) 1977 Long-Term Carcinogenicity
TR-003 PDF (1MB) Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity (CASRN 71-55-6) 1977 Long-Term Carcinogenicity
TR-002 PDF (20MB) Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6) 1976 Long-Term Carcinogenicity
TR-001 PDF (3MB) Guidelines for Carcinogen Bioassay in Small Rodents 1976 Long-Term Carcinogenicity
TR-000 (67-66-3) PDF (2MB) Report on the Carcinogenesis Bioassay of Chloroform (CASRN 67-66-3) 1976 Long-Term Carcinogenicity
TR-000 (143-50-0) PDF (993KB) Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0) 1976 Long-Term Carcinogenicity

Micronucleus Test

The testing protocol has been published and contains more information. Detailed explanations of the micronucleus assay methods and cell scoring are also available.

Overview

The micronucleus test examines the ability of substances to cause damage to chromosomes. Abnormal chromosome counts, chromosomal rearrangements, and chromosomal damage have been linked to birth defects, infertility, and cancer.

Methodology

Animals are treated with a test substance and the frequency of micronucleated cells is determined after exposure. If treated animals show significantly higher frequencies of micronucleated cells than untreated animals, the test substance is considered capable of causing chromosomal damage.

  1. Bone Marrow Assays

    The test subjects are male rodents that are exposed to the test substance either orally or by injection. One to three treatments of the test substance are administered at 24-hour intervals up to the maximum tolerated dose. Bone marrow samples are taken 24 hours after the last dose, and red blood cells are examined for the presence of micronuclei.

  2. Micronucleus Analysis

    Micronucleus tests are performed on mice being treated in 13-week toxicity studies. The test subjects are male and female rodents that are exposed to the test substance orally, dermally, or through inhalation. At the end of the 13-week exposure period, bone marrow samples are taken and red blood cells are examined for the presence of micronuclei. Samples are examined using standard slide scoring procedures and flow cytometric analysis.

Analysis

The data is analyzed to determine if there is an overall increase in the frequency of cells containing micronuclei. Samples from treated animals are compared to samples from untreated animals and any statistical differences in the data are recorded.

Factors that may affect micronucleus test data include:

  • Dose levels
  • Frequencies of micronucleated cells in the treated vs. non-treated animals
  • Number of animals per dose group
  • Number of doses administered
  • Results of the statistical analyses
  • Route of administration
  • Sample time (interval between last dosing and harvesting of cells for analysis)
  • Tissue and cell type being analyzed

The final conclusions for micronucleus tests are determined by considering the results of statistical analyses, reproducibility of any observed effects, and significance of those effects.

Clinical Laboratory Studies

Clinical measurements taken on laboratory study animals provide an important contribution to the overall evaluation of their physiology. Clinical pathology tests often provide information useful for determining the biological significance of findings in toxicity studies not detected by direct examination of organs and tissues.

NTP developed a standard approach for clinical pathology investigations that was integrated into most toxicity studies designed and conducted after 1986. Protocols for these studies include a core set of specific hematology and clinical chemistry analyses selected to permit the evaluation of a variety of organ systems at three different time points in 13-week studies. However, use of a core set does not preclude the inclusion of other clinical pathology tests in a study.

Requirements concerning the anesthetization of animals, collection and analysis of samples, and reporting of results have been established to control sources of variability within and between contract laboratories that perform these studies for NTP.

Clinical measurements include:

  1. Hematology:
    • Erythrocyte count
    • Mean corpuscular volume
    • Hemoglobin
    • Packed cell volume
    • Mean corpuscular hemoglobin
    • Mean corpuscular hemoglobin concentration
    • Erythrocyte morphologic assessment
    • Leukocyte count
    • Leukocyte differential
    • Reticulocyte count
    • Platelet count and morphologic assessment
  2. Clinical Chemistry:
    • Sorbitol dehydrogenase (SDH)
    • Alkaline Phosphatase (ALP)
    • Creatine Kinase (CK)
    • Creatinine
    • Total Protein
    • Albumin
    • Urea Nitrogen (BUN)
    • Total Bile Acids
    • Alanine Aminotransferase (ALT)
    • Glucose
    • Cholesterol
    • Triglycerides

Histopathology List

Tissues examined:

  • Adrenal glands
  • Brain (3 sections including frontal cortex and basal ganglia, parietal cortex and thalamus, and cerebellum and pons)
  • Clitoral glands
  • Esophagus
  • Eyes
  • Femur, including diaphysis with marrow cavity and epiphysis (femoral condyle with epiphyseal cartilage plate, articular cartilage and articular surface)
  • Gallbladder (mouse)
  • Gross lesions
  • Harderian glands
  • Heart and aorta
  • Intestine, large (cecum, colon, rectum)
  • Intestine, small (duodenum, jejunum, ileum)
  • Kidneys
  • Larynx (inhalation studies)
  • Liver (2 sections including left lateral lobe and median lobe)
  • Lungs and mainstem bronchi
  • Lymph nodes
    • mandibular and mesenteric
    • bronchial & mediastinal (inhalation studies)
  • Mammary gland with adjacent skin
  • Muscle, thigh (only if neuromuscular signs were present)
  • Nasal cavity and nasal turbinates (3 sections)
  • Ovaries
  • Pancreas
  • Parathyroid glands
  • Pituitary gland
  • Preputial glands
  • Prostate
  • Salivary glands
  • Seminal vesicle
  • Skin, site of application (dermal studies)
  • Spinal cord and sciatic nerve (if neurologic signs were present)
  • Spleen
  • Stomach (forestomach and glandular)
  • Testes with epididymides
  • Thymus
  • Thyroid gland
  • Tissue masses
  • Trachea
  • Urinary bladder
  • Uterus

Necropsy List

A complete gross necropsy is an external examination of the animal including body orifices and examination and fixation of all of the following organs/tissues from animals from all treatment groups for histopathologic examination.

  • Adrenal glands
  • Brain
  • Clitoral glands
  • Esophagus
  • Eyes
  • Femur
  • Gallbladder (mouse)
  • Gross lesions
  • Harderian glands
  • Heart and aorta
  • Intestine, large (cecum, colon, rectum)
  • Intestine, small (duodenum, jejunum, ileum)
  • Kidneys
  • Liver
  • Lungs and mainstem bronchi
    • mandibular and mesenteric
    • bronchial mediastinal (inhalation studies)
  • Mammary gland with adjacent skin
  • Muscle, thigh
  • Nerve, sciatic
  • Nasal cavity and nasal turbinates
  • Oral cavity, larynx, and pharynx
  • Ovaries
  • Pancreas
  • Parathyroid glands
  • Pituitary gland
  • Preputial glands
  • Prostate
  • Salivary glands
  • Seminal vesicles
  • Skin, site of application (dermal studies)
  • Spinal cord
  • Spleen
  • Stomach (forestomach and glandular)
  • Testes, epididymides, and vaginal tunics of testes
  • Thymus
  • Thyroid gland
  • Tissue masses
  • Tongue
  • Trachea
  • Urinary bladder
  • Uterus
  • Vagina
  • Zymbal glands