Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Phenol 10076-N

 

CASRN: 108-95-2

Formula: C6-H6-O

Synonyms/Common Names

  • Carbolic acid
  • Hydroxybenzene
  • Phenyl hydroxide

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C50124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Water)  (C50124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 100, 10000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Water)  (C50124)  Completed 
    • TR-203 (NIH Number: 80-1759)  (Peer Review Approval 02/15/1980A )
      Bioassay of Phenol for Possible Carcinogenicity (CASRN108-95-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 2500, 5000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (170681)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Chromosome Aberrations  (329606)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Drosophila  (726780)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (340985)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (874983)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (987728)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (175560)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (759552)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Sister Chromatid Exchanges  (170681)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
  • Sister Chromatid Exchanges  (329606)  Completed 
    • Mice
    • Sister Chromatid  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER80129)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 70, 140, 280 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER81104)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 30, 60, 120 MG/KG/DAY.
  • 28 days Immunotoxicity (Dosed-Water)  (IMM20203)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 5, 20, or 100 mg/L.
  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98026)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative