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Testing Status of Dimethylcarbamoyl chloride 10416-L

CASRN: 79-44-7

Formula: C3-H6-Cl-N-O

Synonyms/Common Names

  • Carbamic chloride, dimethyl-
  • Dimethylcarbamyl chloride

Long-Term Carcinogenicity

  • lifetime (Inhalation)  (C08333)  Completed 
    • Rats: Sprague Dawley; Hamsters: Syrian Golden
    • Dose: H: 0, 1 PPM R: 0, .3.1.10 PPM /50-100 ANIMALS PER GROUP.

Genetic Toxicology

  • Drosophila  (264726)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (650170)  Completed 
    • Citation: Yoon JS, Mason JM, Valencia R, Woodruff RC, Zimmering S. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(3):349-67. doi: 10.1002/em.2860070310
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Drosophila  (696783)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • In Vitro Cytogenetics (CA/SCE)  (751170)  Completed 
    • Citation: Galloway SM, Bloom AD, Resnick M, Margolin BH, Nakamura F, Archer P, Zeiger E. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen. 1985;7(1):1-51. doi: 10.1002/em.2860070102
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (754170)  Completed 
    • Citation: Galloway SM, Bloom AD, Resnick M, Margolin BH, Nakamura F, Archer P, Zeiger E. Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: comparison of results for 22 compounds in two laboratories. Environ Mutagen. 1985;7(1):1-51. doi: 10.1002/em.2860070102
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (152755)  Completed 
    • Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
    • Mice
  • Mouse Lymphoma  (348877)  Completed 
    • Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
    • Mice
  • Salmonella  (112665)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (219993)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (439335)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (512993)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (805729)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Positive 
  • Salmonella  (N-9094)  Completed 
    • Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251