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Testing Status of Acrolein 10515-N

CASRN: 107-02-8

Formula: C3-H4-O

Synonyms/Common Names

  • Acraldehyde
  • 2-Propenal

Short-Term Toxicity

  • 13 weeks (Gavage)  (C02802C)  Completed 
    • TOX-48 (NIH Number: 06-4413)
      Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.75, 1.25, 2.5, 5, OR 10 MG/KG M: 0, 1.25, 2.5, 5, 10, OR 20 MG/KG; 10 PER GROUP.

Genetic Toxicology

  • Drosophila  (395759)  Completed 
    • Citation: Zimmering S, Mason JM, Valencia R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ Mol Mutagen. 1989;14(4):245-51. doi: 10.1002/em.2850140406
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (472710)  Completed 
    • Citation: Zimmering S, Mason JM, Valencia R, Woodruff RC. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ Mutagen. 1985;7(1):87-100. doi: 10.1002/em.2860070105
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (134448)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A59477)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (326814)  Completed 
    •  Negative 
  • Salmonella  (326815)  Completed 
    •  Negative 
  • Salmonella  (870479)  Completed 
    • Citation: Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142
    •  Weakly Positive