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Testing Status of Chlorodibromomethane 10570-R

CASRN: 124-48-1

Formula: C-H-Br2-Cl

Synonyms/Common Names

  • Dibromochloromethane

Short-Term Toxicity

  • 14-Day (Gavage)  (C55254)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55254)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 15, 25 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C55254)  Completed 
    • TR-282 (NIH Number: 85-2538)  (Peer Review Approval 03/23/1984A )
      Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 40, 80, M: 0, 50, 100 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (687058)  Completed 
    • Mice
    •  Positive 
  • Drosophila  (558894)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. X. Results of 70 coded chemicals tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(3):208-27. doi: 10.1002/em.2850230310
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (096876)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (261721)  Completed 
    • Citation: Loveday KS, Anderson BE, Resnick MA, Zeiger E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. V: Results with 46 chemicals. Environ Mol Mutagen. 1990;16(4):272-303. doi: 10.1002/em.2850160409
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (306321)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (988921)  Completed 
    • Citation: McGregor DB, Brown AG, Howgate S, McBride D, Riach C, Caspary WJ. Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals. Environ Mol Mutagen. 1991;17(3):196-219. doi: 10.1002/em.2850170309
    • Mice
    •  Positive 
  • Salmonella  (065376)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A32951)  Completed 
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (687058)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • 28 days Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94003)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 50, 150, OR 450 PPM.