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Testing Status of Dimethyl morpholinophosphoramidate 10641-C

CASRN: 597-25-1

Formula: C6-H14-N-O4-P

Synonyms/Common Names

  • Phosphonic acid, 4-morpholinyl-, dimethyl ester

Short-Term Toxicity

  • 14-Day (Gavage)  (C54740)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54740)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 200, 1600 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54740)  Completed 
    • TR-298 (NIH Number: 86-2554)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate (CASRN 597-25-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 150, 300, 600, FM: 0, 300, 600, MM: 0, 150, 300 MG/KG/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Genetic Toxicology

  • Chromosome Aberrations  (963455)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • Drosophila  (475748)  Completed 
    • Citation: Foureman P, Mason JM, Valencia R, Zimmering S. Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ Mol Mutagen. 1994;23(1):51-63. doi: 10.1002/em.2850230109
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • In Vitro Cytogenetics (CA/SCE)  (499883)  Completed 
    • Citation: Gulati DK, Witt K, Anderson B, Zeiger E, Shelby MD. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ Mol Mutagen. 1989;13(2):133-93. doi: 10.1002/em.2850130208
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Mouse Lymphoma  (652921)  Completed 
    • Citation: Myhr BC, Caspary WJ. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environ Mol Mutagen. 1991;18(1):51-83. doi: 10.1002/em.2850180109
    • Mice
    •  Positive 
  • Salmonella  (960949)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Sister Chromatid Exchanges  (963445)  Completed 
    • Mice
    • Sister Chromatid  Not a Valid Test 
  • Sister Chromatid Exchanges  (963455)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)