Testing Status of Methoxychlor 10863-K
CASRN: 72-43-5
Related: KID PEST PROJECT (METHOXYCHLOR)
Formula: C16-H15-Cl3-O2
Synonyms/Common Names
- 1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene) (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00497)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C00497)
Completed
- Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0, 316, 3160, M: 0, 1000, 10000 PPM/5 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00497)
Completed
- TR-035 (NIH Number: 78-835)
(Peer Review Approval 11/18/1977A )
Bioassay of Methoxychlor for Possible Carcinogenicity (CASRN 72-43-5) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: MR: 0, 448, 845 (AVG), FR: 0, 750, 1385 (AVG), MM: 0, 1746, 3491 (AVG), FM: 0, 997, 1994 (AVG) PPM/50 PER GROUP.
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- TR-035 (NIH Number: 78-835)
(Peer Review Approval 11/18/1977A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(344617)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- In Vitro Cytogenetics (CA/SCE)
(639870)
Completed
- Sister Chromatid Exchange Not a Valid Test
- Chromosome Aberrations Negative
- Mouse Lymphoma
(G16413)
Completed
- Citation: Myhr BC, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ Mol Mutagen. 1988;12 Suppl 13:103-94. doi: 10.1002/em.2860120505
- Mice
- Mouse Lymphoma
(G84704)
Completed
- Citation: Mitchell AD, Rudd CJ, Caspary WJ. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: intralaboratory results for sixty-three coded chemicals tested at SRI International. Environ Mol Mutagen. 1988;12 Suppl 13:37-101. doi: 10.1002/em.2860120504
- Mice
- Salmonella
(391422)
Completed
- Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
- Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
- Negative
- Salmonella
(684566)
Completed
- Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
- Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
- Negative
- Salmonella
(N-9092)
Completed
- Citation: Dunkel VC, Zeiger E, Brusick D, McCoy E, McGregor D, Mortelmans K, Rosenkranz HS, Simmon VF. Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ Mutagen. 1984;6 Suppl 2:1-251. doi: 10.1002/em.2860060702
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251