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Testing Status of 2,5-Dithiobiurea 10905-C

CASRN: 142-46-1

Formula: C2-H6-N4-S2

Synonyms/Common Names

  • 1,2-Hydrazinedicarbothioamide

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03009)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03009)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .04, .3, M: 0, .125, 2.0 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03009)  Completed 
    • TR-132 (NIH Number: 79-1387)  (Peer Review Approval 10/25/1978A )
      Bioassay of 2,5-Dithiobiurea for Possible Carcinogenicity (CASRN 142-46-1)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .6, 1.2, M: 0, 1.0, 2.0 %/50 PER GROUP.
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Equivocal 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (225305)  Completed 
    • Citation: Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin B, Resnick M, Anderson B, and Zeiger E. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals. Environ Mol Mutagen. 1987;10 Suppl 10:1-175. doi: 10.1002/em.2850100502
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (959958)  Completed 
    • Citation: Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen. 1986;8 Suppl 7:1-119
    •  Negative