Testing Status of 2,5-Dithiobiurea 10905-C
CASRN: 142-46-1
Formula: C2-H6-N4-S2
Synonyms/Common Names
- 1,2-Hydrazinedicarbothioamide
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03009)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C03009)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, .04, .3, M: 0, .125, 2.0 %/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03009)
Completed
- TR-132 (NIH Number: 79-1387)
(Peer Review Approval 10/25/1978A )
Bioassay of 2,5-Dithiobiurea for Possible Carcinogenicity (CASRN 142-46-1) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Equivocal
- Dose: R: 0, .6, 1.2, M: 0, 1.0, 2.0 %/50 PER GROUP.
- TR-132 (NIH Number: 79-1387)
(Peer Review Approval 10/25/1978A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(225305)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Salmonella
(959958)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative