Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Phenesterin 10940-N


CASRN: 3546-10-9

Formula: C39-H59-Cl2-N-O2

Synonyms/Common Names

  • Cholest-5-en-3-ol (3beta)-, 4-(bis(2-chloroethyl)amino)benzeneacetate

Short-Term Toxicity

  • 14-Day (Gavage)  (C01558)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Gavage)  (C01558)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0, 1.0, 20, M: 0, 1.7, 136 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C01558)  Completed 
    • TR-060 (NIH Number: 78-1310)  (Peer Review Approval 03/06/1978A )
      Bioassay of Phenesterin for Possible Carcinogenicity (CASRN 3546-10-9)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 5, 10, M: 0, 15, 30 MG/KG/15 PER GROUP.

Genetic Toxicology

  • Drosophila  (422979)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (012521)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (461280)  Completed 
    •  Negative 
  • Salmonella  (612071)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative