Testing Status of Perfluorohexanoic acid (PFHXA) M040048

CASRN: 307-24-4

Formula: C6-H-F11-O2

Synonyms/Common Names

• C6 Carboxylic acid
• Hexanoic acid, undecafluoro-

Short-Term Toxicity

• 14 days (Gavage)  (C04048)  On Test 
  • Rats: Hsd:Sprague Dawley SD
  • Dose: 0, 0.25, 5, 25, 100, 500 mg/kg.
• 28 days (Gavage)  (C20613)  Completed 
  • TOX-97 
    Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised)
  • Rats: Harlan Sprague-Dawley
  • Dose: M&F: 0, 31.3, 62.5, 125, 250, or 500 mg/kg/2x day.
• 1 day (Gavage)  (C04048B)  On Test 
  • Series Dose Escalation Cardiovascular Functional Assessment Study
  • Rats: Hsd:Sprague Dawley SD
  • Dose: Dose escalation, Single dose + recovery per dose level 0, 0.25, 5, 25, 100, 500 mg/kg.

Special Studies

• Toxicokinetic Study (Gavage; Intravenous)  (K10128)  Completed 
  • Citation: Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR. Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration. Xenobiotica. 2020 Jun;50(6):722-732. doi: https://doi.org/10.1080/00498254.2019.1683776. Epub 2019 Nov 7.Pubmed Abstract
  • Male and Female Rats: Hsd:Sprague Dawley SD
  • Dose: 40 mg/kg. 40, 80, and 160 mg/kg.

Genetic Toxicology

• Micronucleus  (G04048)  Completed 
  • Rats: Harlan Sprague-Dawley
  • Male Equivocal 
  • Female Negative 
• Salmonella  (A97455)  Completed 
  •  Negative