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Testing Status of Furosemide 10068-N

 

CASRN: 54-31-9

Formula: C12-H11-Cl-N2-O5-S

Synonyms/Common Names

  • 5-(Aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)benzoic acid (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55936)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55936)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 625, 10000, FR&MM: 0, 938, 15000, FM: 0, 1250, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 107 weeks (Dosed-Feed)  (C55936)  Completed 
    • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 350, 700, M: 0, 700, 1400 PPM/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C55936)  Completed 
    • TR-356 (NIH Number: 89-2811)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 350, 700, M: 0, 700, 1400 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (169457)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (912768)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (219163)  Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    • Mice
    •  Positive 
  • Salmonella  (312303)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A84903)  Completed 
    •  Negative