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Testing Status of Isophorone 10070-P

 

CASRN: 78-59-1

Formula: C9-H14-O

Synonyms/Common Names

  • 3,5,5-Trimethyl-2-cyclohexen-1-one (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55618)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55618)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 62.5, 1000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C55618)  Completed 
    • TR-291 (NIH Number: 86-2547)  (Peer Review Approval 11/02/1984A )
      Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 250, 500 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (783723)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (719644)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (624279)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (490210)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (505090)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (783723)  Completed 
    • Mice
    • Sister Chromatid  Negative