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Testing Status of Diethyl phthalate 10112-F

 

CASRN: 84-66-2

Formula: C12-H14-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, diethyl ester
  • DEP

Short-Term Toxicity

  • 4 weeks (Topical Application)  (C60048B)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C60048B)  Completed 
    • TR-429 (NIH Number: 95-3356)  (Peer Review Approval 11/17/1993A )
      Toxicology and Carcinogenesis Studies of Diethylphthalate in F344/N Rats and B6C3F1 Mice (Dermal Studies) with Dermal Initiation/Promotion Study of Diethylphthalate and Dimethylphthalate in Male Swiss (CD-1) Mice
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, 100, 300 M: 0, 7.5, 15, 30 UL/100 UL SOLUTION /50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Topical Application)  (S0044)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (306322)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (913646)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (364986)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (576172)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83092)  Completed 
    • Citation: Lamb JC 4th, Chapin RE, Teague J, Lawton AD, Reel JR. Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl Pharmacol. 1987 Apr;88(2):255-69. doi: https://doi.org/10.1016/0041-008x(87)90011-1.
    • Citation: National Toxicology Program (NTP). 1984. Diethyl phthalate (CASRN 84-66-2): Reproduction and fertility assessment in CD-1 mice when administered in the feed. Research Triangle Park, NC: National Toxicology Program. RACB Report 83092. https://ntp.niehs.nih.gov/go/racb83092abs
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .25, 1.25, 2.5% IN FEED; N/A; 0, 2.5%.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88065)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0.25, 2.5, 5.0 %.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0033A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 4500 MG/KG BODY WEIGHT.
  • Utero-Lactational (Gavage)  (R10112)  Completed 
    • Rats: Harlan Sprague-Dawley