Testing Status of Pentaerythritol tetranitrate 10150-E
CASRN: 78-11-5
Formula: C5-H8-N4-O12
Synonyms/Common Names
- 2,2-Bis((nitrooxy)-methyl)-1,3-propanediol dinitrate(ester) (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55743)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C55743)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, .31, 5 %/5 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C55743)
Completed
- TR-365 (NIH Number: 89-2820)
(Peer Review Approval 10/04/1988A )
Toxicology and Carcinogenesis Studies of Pentaerythritol Tetranitrate (CASRN 78-11-5) with 80% D-Lactose Monohydrate (PETN, NF) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Equivocal Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: FR: 0, 6200, 12500, MR&M: 0, 25000, 50000 PPM.
- TR-365 (NIH Number: 89-2820)
(Peer Review Approval 10/04/1988A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(896240)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Salmonella
(388086)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative