Testing Status of Allyl isothiocyanate 10367-A
CASRN: 57-06-7
Formula: C4-H5-N-S
Synonyms/Common Names
- 3-Isothiocyanato-1-propene
Short-Term Toxicity
- 14-Day (Gavage)
(C50464)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C50464)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 1.5, 25 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C50464)
Completed
- TR-234 (NIH Number: 83-1790)
(Peer Review Approval 06/23/1981A )
Carcinogenesis Bioassay of Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and B6C3F1 Mice (Gavage Study) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Equivocal
- Male Mice Negative
- Female Mice Negative
- Dose: 0, 12, 25 MG/KG/50 PER GROUP.
- TR-234 (NIH Number: 83-1790)
(Peer Review Approval 06/23/1981A )
Special Studies
- Absorption Disposition Metabolism Elimination (Intravenous)
(S0742)
Completed
- Citation: Ioannou YM, Burka LT, Matthews HB. Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol. 1984 Sep 15;75(2):173-81.Pubmed Abstract
- Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
- Dose: 2.5 mg/kg, 25 mg/kg.
- Metabolism (Gavage)
(S0743)
Completed
- Citation: Borghoff SJ, Birnbaum LS. Age-related changes in the metabolism and excretion of allyl isothiocyanate. A model compound for glutathione conjugation. Drug Metab Dispos. 1986 Jul-Aug;14(4):417-22.Pubmed Abstract
- Male Rats: F344/N
- Dose: 25 mg/kg.
Genetic Toxicology
- Chromosome Aberrations
(056227)
Completed
- Mice
- Equivocal
- Chromosome Aberrations
(A59578)
Completed
- Mice
- Negative
- Drosophila
(010317)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Drosophila
(913948)
Completed
- Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(630852)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(896173)
Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A41461)
Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A59578)
Completed
- Mice: B6C3F1
- Male Negative
- Mouse Lymphoma
(352025)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(521783)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(649249)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Weakly Positive
- Sister Chromatid Exchanges
(056227)
Completed
- Mice
- Sister Chromatid Positive