Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Bromodichloromethane 10397-Y

 

CASRN: 75-27-4

Formula: C-H-Br-Cl2

Synonyms/Common Names

  • Dichlorobromomethane

Short-Term Toxicity

  • 14-Day (Gavage)  (C55243)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55243)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 19, 300, MM: 0, 6.25, 100, FM: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 108 weeks (Gavage)  (C55243)  Completed 
    • TR-321 (NIH Number: 88-2537)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 50, 100 MM:0, 25, 50 FM: 0, 75, 150 MG/KG/50 PER GROUP.
  • 2 years (Gavage)  (C55243)  Completed 
    • TR-321 (NIH Number: 88-2537)  (Peer Review Approval 08/19/1986A )
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 50, 100 MM:0, 25, 50 FM: 0, 75, 150 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0097)  Completed 
    • Citation: Mathews JM, Troxler PS, Jeffcoat AR. Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses. J Toxicol Environ Health. 1990 May;30(1):15-22.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: S:1, 10, 32, 100; M:10, 100 MG/KG X 10 DAYS.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0527)  Completed 
    • Male Rats: F344/N
    • Dose: 1, 10, 32 & 100 MG/KG.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K05097)  Completed 
    • Rats: Fischer 344; Mice: B6C3F1
  • Toxicokinetic Study (Gavage)  (S0644)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (494532)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A08959)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A38548)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Equivocal 
    • Female Equivocal 
  • Micronucleus  (A39408)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A42280)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A55870)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A78486)  Completed 
    • Mice: B6C3F1
    • Female Negative 
  • Micronucleus  (A90924)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Equivocal 
    • Female Negative 
  • Mouse Lymphoma  (173442)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (038604)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A68248)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 35 days Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94017)  Completed 
    • Rats: Sprague Dawley