Testing Status of Carbromal 10408-L

CASRN: 77-65-6

Formula: C7-H13-Br-N2-O2

Synonyms/Common Names

• Biogastrone
• N-(Aminocarbonyl)-2-bromo-2-ethylbutanamide

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03805)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03805)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0, 1470, 14700 PPM/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03805)  Completed 
  • TR-173 (NIH Number: 79-1729)  (Peer Review Approval 08/31/1978A )
    Bioassay of Carbromal for Possible Carcinogenicity (CASRN 77-65-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Negative 
    • Female Rats Negative 
    • Male Mice Negative 
    • Female Mice Negative 
  • Dose: 0, 1250, 2500 PPM/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (157167)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• In Vitro Cytogenetics (CA/SCE)  (480465)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Positive 
• Salmonella  (332501)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (652507)  Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative