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Testing Status of Butyl benzyl phthalate 10422-E

 

CASRN: 85-68-7

Formula: C19-H20-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C54375A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C54375A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1600, 25000 PPM/10 PER GROUP.
  • 26 weeks (Dosed-Feed)  (C54375B)  Completed 
    • Rats: F344/N
    • Dose: 0, .16, 2.5 %/10 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Dosed-Feed)  (C54375A)  Completed 
    • TR-213 (NIH Number: 82-1769)  (Peer Review Approval 06/23/1981A )
      Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344/N Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 6000, 12000 PPM/50 PER GROUP.
  • 2 & 3 years (Dosed-Feed)  (C54375C)  Completed 
    • TR-458 (NIH Number: 97-3374)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats (Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
    • Dose: MR: 0, .3%, .6%, OR 1.2%; 60/GROUP FR: 0, .6%, 1.2%, OR 2.4%; 60/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0049)  Completed 
    • Male Rats
    • Dose: 20 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0673)  Completed 
    • Citation: Eigenberg DA, Bozigian HP, Carter DE, Sipes IG. Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat. J Toxicol Environ Health. 1986;17(4):445-56.Pubmed Abstract
    • Rats

Genetic Toxicology

  • Chromosome Aberrations  (336452)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (833451)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (312362)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (811311)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Micronucleus  (A61034)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (834175)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (933175)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Sister Chromatid Exchanges  (336452)  Completed 
    • Mice
    • Sister Chromatid  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Feed)  (T0150B)  Completed 
    • Rats: F344/N
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88025)  Completed 
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0.5, 1.25, 2.0%.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER89026)  Completed 
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0.1, 0.5, 1.25. 2.0%.
  • Utero-Lactational (Dosed-Feed)  (R10422)  Completed 
    • Rats: Fischer 344