Testing Status of Ethylene thiourea (ETU) 10466-C
CASRN: 96-45-7
Formula: C3-H6-N2-S
Synonyms/Common Names
- 2-Imidazolidinethione (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03372)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C03372)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 60, 750, M: 0, 125, 2000 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C03372)
Completed
- TR-388 (NIH Number: 92-2843)
(Peer Review Approval 04/25/1990A )
Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 25, 83, 250, M: 0, 100, 333, 1000 PPM/50 PER GROUP.
- TR-388 (NIH Number: 92-2843)
(Peer Review Approval 04/25/1990A )
Genetic Toxicology
- Drosophila
(118681)
Completed
- Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
- Sex-Linked Recessive Lethal Equivocal
- Reciprocal Translocation Negative
- Drosophila
(717564)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(007998)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Mouse Lymphoma
(669405)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(123790)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(431394)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Weakly Positive
Organ Systems Toxicity
- Immunotoxicity (Topical Application)
(IMM90009)
Completed
- Female Mice: B6C3F1
- Mice Female Positive
- Dose: 0, 1, 3, 10%.
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0042A)
Completed
- Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
- Female Mice: Swiss
- Dose: 600 MG/KG BD WT.
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0042B)
Completed
- Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
- Female Mice: Swiss
- Dose: 300 MG/KG BD WT.
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0042C)
Completed
- Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
- Female Mice: Swiss
- Dose: 200 MG/KG BD WT.
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0042D)
Completed
- Citation: Screening of Priority Chemicals for Reproductive Hazards
- Female Mice: Swiss
- Dose: 100 MG/KG BD WT.