Testing Status of Ethylene thiourea (ETU) 10466-C

CASRN: 96-45-7

Formula: C3-H6-N2-S

Synonyms/Common Names

• 2-Imidazolidinethione (9CI)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03372)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03372)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 60, 750, M: 0, 125, 2000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C03372)  Completed 
  • TR-388 (NIH Number: 92-2843)  (Peer Review Approval 04/25/1990A )
    Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Clear Evidence 
    • Female Rats Clear Evidence 
    • Male Mice Clear Evidence 
    • Female Mice Clear Evidence 
  • Dose: R: 0, 25, 83, 250, M: 0, 100, 333, 1000 PPM/50 PER GROUP.

Genetic Toxicology

• Drosophila  (118681)  Completed 
  • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
  • Sex-Linked Recessive Lethal Equivocal 
  • Reciprocal Translocation Negative 
• Drosophila  (717564)  Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• In Vitro Cytogenetics (CA/SCE)  (007998)  Completed 
  • Sister Chromatid Exchange Negative 
  • Chromosome Aberrations Negative 
• Mouse Lymphoma  (669405)  Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  • Mice
  •  Positive 
• Salmonella  (123790)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (431394)  Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Weakly Positive 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM90009)  Completed 
  • Female Mice: B6C3F1
  • Mice Female Positive 
  • Dose: 0, 1, 3, 10%.
• 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0042A)  Completed 
  • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • Female Mice: Swiss
  • Dose: 600 MG/KG BD WT.
• 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0042B)  Completed 
  • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
  • Female Mice: Swiss
  • Dose: 300 MG/KG BD WT.
• 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0042C)  Completed 
  • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • Female Mice: Swiss
  • Dose: 200 MG/KG BD WT.
• 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0042D)  Completed 
  • Citation: Screening of Priority Chemicals for Reproductive Hazards
  • Female Mice: Swiss
  • Dose: 100 MG/KG BD WT.