Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of p-Chloro-a,a,a-trifluorotoluene 10472-T

 

CASRN: 98-56-6

Formula: C7-H4-Cl-F3

Synonyms/Common Names

  • Benzene, 1-chloro-4-(trifluoromethyl)-
  • 1-Chloro-4-(trifluoromethyl)benzene
  • CTFT
  • PCBTF
  • p-Chlorobenzotrifluoride
  • PCTFT

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88002)  Completed 
    • TOX-14 (NIH Number: 92-3133)  (Peer Review Approval 03/11/1991A )
      Toxicity Studies of p-Chloro-a,a,a-Trifluorotoluene (CASRN: 98-56-6) Administered in Corn Oil and a-Cyclodextrin to F344/N Rats and B6C3F1 Mice in 14-Day Comparative Gavage Studies
    • Rats: F344/N; Mice: B6C3F1
    • Dose: Dose: R&M: 0, 50, 500, or 1000 mg/kg/15 per group; includes 5 additional male rats per group for special studies: ELISA; prep of H&E, and Mallory's Heidenhain stained kidney sections for microscopic examination, hyaline droplets; CTFT levels in blood, kidney, liver.
  • 2 weeks (Gavage)  (C88002B)  Completed 
    • TOX-14 (NIH Number: 92-3133)  (Peer Review Approval 03/11/1991A )
      Toxicity Studies of p-Chloro-a,a,a-Trifluorotoluene (CASRN: 98-56-6) Administered in Corn Oil and a-Cyclodextrin to F344/N Rats and B6C3F1 Mice in 14-Day Comparative Gavage Studies
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 50, 500, or 1000 mg/kg/15 per group; includes 5 additional male rats per group for special studies: ELISA; prep of H&E, and Mallory's Heidenhain stained kidney sections for microscopic examination, hyaline droplets; CTFT levels in blood, kidney, liver.
  • 90 days (Inhalation)  (C10472)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R&M: 0, 125, 250, 500, 1000, or 2000 ppm; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C10472B)  Completed 
    • TR-594   (Peer Review Approval 07/13/2017A )
      Toxicology and Carcinogenesis Studies of p-Chloro-a,a,a-trifluorotoluene (CASRN 98-56-6) in Sprague Dawley Rats (Hsd:Sprague Dawley SD) and B6C3F1/N Mice (Inhalation Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 100, 300, or 1000 ppm; M: 0, 100, 200, or 400 ppm; 50/sex/species.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0406)  Completed 
    • Citation: Yuan JM, Jameson CW, Goehl TJ, Collins BJ, Purdie W, Judd L. Application of molecular encapsulation for toxicology studies: toxicokinetics of p-chloro-alpha,alpha,alpha-trifluorotoluene in alpha-cyclodextrin or corn oil vehicles in male F344 rats. Toxicol Appl Pharmacol. 1991 Oct;111(1):107-15. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 10, 50, 200, or 400 mg/kg, alpha-cyclodextrin. 10, 50, or 400 mg/kg, corn oil.

Genetic Toxicology

  • Micronucleus  (G10472)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (G10472B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Equivocal 
  • Salmonella  (176994)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (G10472C)  Completed