Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1-Phenyl-2-thiourea 10500-K

 

CASRN: 103-85-5

Formula: C7-H8-N2-S

Synonyms/Common Names

  • Phenylthiourea (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02017)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02017)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 45, 215, M: 0, 25, 810 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02017)  Completed 
    • TR-148 (NIH Number: 78-1704)  (Peer Review Approval 06/25/1978A )
      Bioassay of 1-Phenyl-2-thiourea for Possible Carcinogenicity (CASRN 103-85-5)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 60, 120, M: 0, 150, 300 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (575473)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (688781)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (155526)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative