Testing Status of Epichlorhydrin 10512-C

CASRN: 106-89-8

Formula: C3-H5-Cl-O

Synonyms/Common Names

• alpha-Epichlorohydrin
• Oxirane, (chloromethyl)-

Long-Term Carcinogenicity

• lifetime (Inhalation)  (C07001)  Completed 
  • Rats: Sprague Dawley
  • Dose: R: 0, 100 PPM /100 ANIMALS PER GROUP.

Genetic Toxicology

• Comet Assay  (G10512B)  Completed 
  • Mice
• In Vitro Cytogenetics (CA/SCE)  (099989)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (G10512)  Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (365601)  Completed 
  • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
  •  Positive