Testing Status of 1,3-Butadiene 10514-J
CASRN: 106-99-0
Formula: C4-H6
Synonyms/Common Names
- alpha,gamma-Butadiene
Short-Term Toxicity
- 13 weeks (Inhalation)
(C50602B)
Completed
- Rats: F344/N
- Dose: R: 0, 200, 625, 2000, OR 6250 PPM M: 0, 625, 1250, 5000, 8000, OR 16000 PPM.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C50602A)
Completed
- TR-288 (NIH Number: 84-2544)
(Peer Review Approval 10/28/1983A )
Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: 0, 625, 1250 PPM/50 PER GROUP.
- TR-288 (NIH Number: 84-2544)
(Peer Review Approval 10/28/1983A )
- 2 years (Inhalation)
(C50602C)
Completed
- TR-434 (NIH Number: 92-3165)
(Peer Review Approval 11/21/1991A )
Toxicology and Carcinogenesis Studies of 1,3-Butadiene in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: 0, 6.25, 20, 62.5, 200, 625 PPM/50 PER GROUP.
- TR-434 (NIH Number: 92-3165)
(Peer Review Approval 11/21/1991A )
- 2 years (Inhalation)
(C50602D)
Completed
- Citation: Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
- Mice: B6C3F1
- Dose: Mice only: 0, 1000, 5000, 10000 ppm/60 per group.
Special Studies
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0220)
Completed
- Citation: Dahl AR, Bechtold WE, Bond JA, Henderson RF, Mauderly JL, Muggenburg BA, Sun JD, Birnbaum LS. Species differences in the metabolism and disposition of inhaled 1,3-butadiene and isoprene. Environ Health Perspect. 1990 Jun;86:65-9.Pubmed Abstract
- Rats; Mice; Monkeys
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0792)
Completed
- Citation: Bond JA, Dahl AR, Henderson RF, Dutcher JS, Mauderly JL, Birnbaum LS. Species differences in the disposition of inhaled butadiene. Toxicol Appl Pharmacol. 1986 Jul;84(3):617-27.Pubmed Abstract
- Male Rats: Sprague Dawley; Male Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0793)
Completed
- Citation: Bond JA, Martin OS, Birnbaum LS, Dahl AR, Melnick RL, Henderson RF. Metabolism of 1,3-butadiene by lung and liver microsomes of rats and mice repeatedly exposed by inhalation to 1,3-butadiene. Toxicol Lett. 1988 Nov;44(1-2):143-51.Pubmed Abstract
- Male Rats: Sprague Dawley; Male Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0794)
Completed
- Citation: Bond JA, Dahl AR, Henderson RF, Birnbaum LS. Species differences in the distribution of inhaled butadiene in tissues. Am Ind Hyg Assoc J. 1987 Oct;48(10):867-72.Pubmed Abstract
- Male Rats: Sprague Dawley; Male Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0795)
Completed
- Citation: Sabourin PJ, Burka LT, Bechtold WE, Dahl AR, Hoover MD, Chang IY, Henderson RF. Species differences in urinary butadiene metabolites; identification of 1,2-dihydroxy-4-(N-acetylcysteinyl)butane, a novel metabolite of butadiene. Carcinogenesis. 1992 Sep;13(9):1633-8.Pubmed Abstract
- Rats: F344/N; Rats: Sprague Dawley; Mice: B6C3F1; Hamsters: Syrian Golden; Monkeys
- Other (Intraperitoneal Injection)
(S0459)
Completed
- Citation: Sun JD, Dahl AR, Bond JA, Birnbaum LS, Henderson RF. Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene. Toxicol Appl Pharmacol. 1989 Aug;100(1):86-95.Pubmed Abstract
- Male Rats: Sprague Dawley; Male Mice: B6C3F1
- Dose: 1, 10, 100 OR 1000 UMOL [14C]BUTADIENE.
- Toxicokinetic Study (Inhalation)
(S0796)
Completed
- Citation: Dahl AR, Sun JD, Birnbaum LS, Bond JA, Griffith WC Jr, Mauderly JL, Muggenburg BA, Sabourin PJ, Henderson RF. Toxicokinetics of inhaled 1,3-butadiene in monkeys: comparison to toxicokinetics in rats and mice. Toxicol Appl Pharmacol. 1991 Aug;110(1):9-19. Erratum in Toxicol Appl Pharmacol 1992 Sep;116(1):152.Pubmed Abstract
- Rats; Mice; Monkeys
Genetic Toxicology
- Chromosome Aberrations
(A74454)
Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice
- Chromosome Aberrations
(A93093)
Completed
- Mice
- Positive
- Drosophila
(950073)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Micronucleus
(A74454)
Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice: B6C3F1
- Male Positive (Nonstandard Protocol)
- Mouse Lymphoma
(614566)
Completed
- Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
- Mice
- Negative
- Salmonella
(256166)
Completed
- Positive
- Sister Chromatid Exchanges
(A74454)
Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice
Organ Systems Toxicity
- 6 to 15 GD Conventional Teratology (Inhalation)
(TER85144)
Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 40, 200, 1000 PPM.
- 6 to 19 GD Conventional Teratology (Inhalation)
(TER89041)
Completed
- Female Rats: Sprague Dawley
- Rats Maternal Negative
- Rats Fetal Negative
- Dose: 0, 40, 200, 1000 PPM.
- 5 consecutive days Dominant Lethal (Inhalation)
(T0183A)
Completed
- Citation: Hackett PL, Mast TJ, Brown MG, Clark ML, Evanoff, JJ. Dominant Lethal Study in CD-1 Mice Following Inhalation Exposure to 1,3-Butadiene: Final Technical Report. April 1988
- Male Mice: Swiss
- Dose: 200, 1000, or 5000 ppm.