Testing Status of 2-Aminoanthraquinone 10542-A
CASRN: 117-79-3
Formula: C14-H9-N-O2
Synonyms/Common Names
- 2-Amino-9,10-anthracenedione
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01876)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C01876)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 1, 5 %/5 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01876)
Completed
- TR-144 (NIH Number: 78-1399)
(Peer Review Approval 06/29/1978A )
Bioassay of 2-Aminoanthraquinone for Possible Carcinogenicity (CASRN 117-79-3) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Inadequate Study
- Male Mice Positive
- Female Mice Positive
- Dose: FR: 0, .2 (AVG), MR: 0, .35, .69 (AVG), M: 0, .5, 1.0 %/50 PER GROUP.
- TR-144 (NIH Number: 78-1399)
(Peer Review Approval 06/29/1978A )
Special Studies
- C. elegans
(W10542)
Completed
- C. elegans
- Dose: 100, 75, 50 uM.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(230007)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Salmonella
(634899)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
- Salmonella
(N-9402)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248