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Testing Status of Hexachlorobenzene 10546-R

 

CASRN: 118-74-1

Formula: C6-Cl6

Synonyms/Common Names

  • Amatin

Short-Term Toxicity

  • 5 days (Gavage)  (C10546)  Completed 
    • 5-Day Transcriptomic Dose-Response Studies
    • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.004, 0.015, 0.0625, 0.25, 1, 4, 16, or 64 mg/kg; N=4.
  • 13 weeks (Gavage)  (C98004)  Completed 
    • TOX-77 
      Toxicity Studies of Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage to Female Sprague Dawley (Hsd:Sprague Dawley SD) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: Females only: 0, .03, .1, .3, 1, 3, 10, or 25 mg/kg; 10/dose.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0654)  Completed 
    • Citation: National Toxicology Program (NTP). 2021. NTP technical report on the toxicity studies of hexachlorobenzene (CASRN 118-74-1) administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program: Toxicity Report 77. https://doi.org/10.22427/NTP-TOX-77
    • Female Rats: Sprague Dawley
    • Dose: Oral dose 30 and 30000 ug/kg/day, single administration and repeat dose (up to 12 weeks) for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals. female rats-gav: 30 and 30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0811)  Completed 
    • Citation: National Toxicology Program (NTP). 2021. NTP technical report on the toxicity studies of hexachlorobenzene (CASRN 118-74-1) administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program: Toxicity Report 77. https://doi.org/10.22427/NTP-TOX-77
    • Female Rats: Sprague Dawley
    • Dose: IV DOSE 1000 AND 100 UG/KG; ORAL DOSE 300 UG/KG.

Genetic Toxicology

  • Salmonella  (880475)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 6 month Continuous Breeding (Legacy) (Gavage)  (RACB99001)  Completed 
    • Citation: Hexachlorobenzene: Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: 1-100 OR 1000 MG/KG/DAY.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T10546)  Completed 
    • 5-Day Transcriptomic Dose-Response Studies
    • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley