Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Hexachlorobenzene 10546-R

 

CASRN: 118-74-1

Formula: C6-Cl6

Synonyms/Common Names

  • Amatin

Short-Term Toxicity

  • 5 days (Gavage)  (C10546)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.004, 0.015, 0.0625, 0.25, 1, 4, 16, or 64 mg/kg; N=4.
  • 13 weeks (Gavage)  (C98004)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: Females only: 0, .03, .1, .3, 1, 3, 10, or 25 mg/kg; 10/dose.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0654)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: female rats-gav: 30 and 30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals. female rats-gav: 30-30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0811)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: IV DOSE 1000 AND 100 UG/KG; ORAL DOSE 300 UG/KG.

Genetic Toxicology

  • Salmonella  (880475)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 6 month Continuous Breeding (Legacy) (Gavage)  (RACB99001)  Completed 
    • Citation: Hexachlorobenzene: Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: 1-100 OR 1000 MG/KG/DAY.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T10546)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley