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Testing Status of Hexachlorobenzene 10546-R

 

CASRN: 118-74-1

Formula: C6-Cl6

Synonyms/Common Names

  • Amatin

Short-Term Toxicity

  • 5 days (Gavage)  (C10546)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.004, 0.015, 0.0625, 0.25, 1, 4, 16, or 64 mg/kg; N=4.
  • 13 weeks (Gavage)  (C98004)  Completed 
    • TOX-77 
      Toxicity Studies of Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage to Female Sprague Dawley (Hsd:Sprague Dawley SD) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: Females only: 0, .03, .1, .3, 1, 3, 10, or 25 mg/kg; 10/dose.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0654)  Completed 
    • Citation: National Toxicology Program (NTP). 2021. NTP technical report on the toxicity studies of hexachlorobenzene (CASRN 118-74-1) administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program: Toxicity Report 77. https://doi.org/10.22427/NTP-TOX-77
    • Female Rats: Sprague Dawley
    • Dose: Oral dose 30 and 30000 ug/kg/day, single administration and repeat dose (up to 12 weeks) for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals. female rats-gav: 30 and 30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0811)  Completed 
    • Citation: National Toxicology Program (NTP). 2021. NTP technical report on the toxicity studies of hexachlorobenzene (CASRN 118-74-1) administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats. Research Triangle Park, NC: National Toxicology Program: Toxicity Report 77. https://doi.org/10.22427/NTP-TOX-77
    • Female Rats: Sprague Dawley
    • Dose: IV DOSE 1000 AND 100 UG/KG; ORAL DOSE 300 UG/KG.

Genetic Toxicology

  • Salmonella  (880475)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 6 month Continuous Breeding (Legacy) (Gavage)  (RACB99001)  Completed 
    • Citation: Hexachlorobenzene: Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: 1-100 OR 1000 MG/KG/DAY.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T10546)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley