Testing Status of Hexachlorobenzene 10546-R
CASRN: 118-74-1
Formula: C6-Cl6
Synonyms/Common Names
- Amatin
Short-Term Toxicity
- 5 days (Gavage)
(C10546)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Male rats: 0, 0.004, 0.015, 0.0625, 0.25, 1, 4, 16, or 64 mg/kg; N=4.
- 13 weeks (Gavage)
(C98004)
Report in Preparation
- Rats: Harlan Sprague-Dawley
- Dose: Females only: 0, .03, .1, .3, 1, 3, 10, or 25 mg/kg; 10/dose.
Special Studies
- Toxicokinetic Study (Gavage; Intravenous)
(S0654)
Completed
- Female Rats: Sprague Dawley
- Dose: female rats-gav: 30 and 30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals. female rats-gav: 30-30000 ug/kg/day (half life det same doses) 13 weeks at 5 days/week, do repeat dose and single admin. for RD: 6 terminal timepts (11, 22, 33, 44, 55, 66 d) at 3 animals/3 retro-orbital timepts (6, 17, 28d) at 6 animals, for SA: 12 terminal timepts (3, 8hr, 1, 2, 3, 7, 11, 22, 33, 44, 55, 66d) at 3 animals/5 reto-orbital blood timepot (30 min, 1, 12 hr, 5, 9 d)at 6 animals.
- Toxicokinetic Study (Gavage; Intravenous)
(S0811)
Completed
- Female Rats: Sprague Dawley
- Dose: IV DOSE 1000 AND 100 UG/KG; ORAL DOSE 300 UG/KG.
Genetic Toxicology
- Salmonella
(880475)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
Organ Systems Toxicity
- 6 month Continuous Breeding (Legacy) (Gavage)
(RACB99001)
Completed
- Citation: Hexachlorobenzene: Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats by Oral Gavage
- Male and Female Rats: Sprague Dawley
- Dose: 1-100 OR 1000 MG/KG/DAY.
Toxicogenomics
- 5 days Transcriptome Sequencing (Gavage)
(T10546)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley