Testing Status of Ethyl acrylate 10594-X
CASRN: 140-88-5
Formula: C5-H8-O2
Synonyms/Common Names
- 2-Propenoic acid, ethyl ester (9CI)
Short-Term Toxicity
- 14-Day (Gavage)
(C50384)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C50384)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 7, 110, M: 0, 12, 100 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 107 weeks (Gavage)
(C50384)
Completed
- TR-259 (NIH Number: 87-2515)
(Peer Review Approval 02/28/1983A )
Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: 0, 100, 200 MG/KG/50 PER GROUP.
- TR-259 (NIH Number: 87-2515)
(Peer Review Approval 02/28/1983A )
- 2 years (Gavage)
(C50384)
Completed
- TR-259 (NIH Number: 87-2515)
(Peer Review Approval 02/28/1983A )
Carcinogenesis Studies of Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: 0, 100, 200 MG/KG/50 PER GROUP.
- TR-259 (NIH Number: 87-2515)
(Peer Review Approval 02/28/1983A )
Special Studies
- Cell Proliferation (Gavage)
(S0287)
Completed
- Citation: Ghanayem BI, Matthews HB, Maronpot RR. Sustainability of fore stomach hyperplasia in rats treated with ethyl acrylate for 13 weeks and regression after cessation of dosing. Toxicol Pathol. 1991;19(3):273-9.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Cell Proliferation (Gavage)
(S0368)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Role of chemically induced cell proliferation in ethyl acrylate-induced forestomach carcinogenesis. Prog Clin Biol Res. 1991;369:337-46.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Cell Proliferation (Gavage)
(S0746)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. I. Effect of single and repetitive dosing. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):323-35.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Cell Proliferation (Gavage)
(S0747)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. III. Development and recovery of lesions. Toxicol Appl Pharmacol. 1986 May;83(3):576-83.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Cell Proliferation (Gavage)
(S0748)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Effects of sulfhydryl modulation on ethyl acrylate-induced forestomach toxicity. Toxicol Lett. 1991 Feb;55(2):215-21.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Cell Proliferation (Gavage)
(S0757)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Association of chemically induced forestomach cell proliferation and carcinogenesis. Cancer Lett. 1986 Sep;32(3):271-8.Pubmed Abstract
- Male Rats: F344/N
- Mechanisms (Gavage)
(S0467)
Completed
- Citation: Ghanayem BI, Maronpot RR, Matthews HB. Ethyl acrylate-induced gastric toxicity. II. Structure-toxicity relationships and mechanism. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):336-44.Pubmed Abstract
- Male Rats: F344/N
- Metabolism (Gavage)
(S0369)
Completed
- Citation: Ghanayem BI, Burka LT, Matthews HB. Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fisher 344 rats. Fundam Appl Toxicol. 1987 Oct;9(3):389-97.Pubmed Abstract
- Male Rats: F344/N
- Dose: 100, 200, 400 mg/kg.
- Metabolism
(S0780)
Completed
- Male and Female Rats: F344/N
Genetic Toxicology
- Chromosome Aberrations
(272157)
Completed
- Mice
- Negative
- Drosophila
(177932)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Drosophila
(518545)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(402439)
Completed
- Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
- Sister Chromatid Exchange Weakly Positive
- Chromosome Aberrations Positive
- In Vitro Cytogenetics (CA/SCE)
(550589)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(270996)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(324746)
Completed
- Negative
- Salmonella
(623002)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
- Salmonella
(749805)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
- Salmonella
(840926)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Weakly Positive
- Sister Chromatid Exchanges
(272157)
Completed
- Mice
- Sister Chromatid Negative
Organ Systems Toxicity
- 4 days, 8 days Immunotoxicity (Topical Application)
(IMM95004)
Completed
- Female Mice: B6C3F1
- Dose: 10, 20, AND 30% IN ACETONE (99.8%) FOR SENSITIZATION AND 30% FOR CHALLENGE; 0.25% DNFB AS POSITIVE CONTROL AND 0.5% FOR CHALLENGE.