Testing Status of 3-Nitropropionic acid 10620-G
CASRN: 504-88-1
Formula: C3-H5-N-O4
Synonyms/Common Names
- beta-Nitropropanoic acid
Short-Term Toxicity
- 13 weeks (Gavage)
(C03076)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 100, 900, M: 0, 150, 800 MG/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C03076)
Completed
- TR-052 (NIH Number: 78-1302)
(Peer Review Approval 01/18/1978A )
Bioassay of 3-Nitropropionic Acid for Possible Carcinogenicity (CASRN 504-88-1) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: MR: 0, .425, .85, FR: 0, .6, 1.2, M: 0, .375, .75 MG/50 PER GROUP.
- TR-052 (NIH Number: 78-1302)
(Peer Review Approval 01/18/1978A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(892866)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Weakly Positive
- Mouse Lymphoma
(G46070)
Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mice
- Mouse Lymphoma
(G63977)
Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mice
- Salmonella
(290153)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Positive
- Salmonella
(N-9198)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248