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Testing Status of D&C Red No. 9 10729-X

 

CASRN: 5160-02-1

Formula: C17-H13-Cl-N2-O4-S.1/2Ba

Synonyms/Common Names

  • 5-Chloro-2-((2-hydroxy-1-naphthalenyl)azo)-4-methylbenzenesulfonic acid, barium salt (2:1)
  • Red No. 9, D&C

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C53792)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C53792)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 3000, 50000, M: 0, 600, 10000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C53792)  Completed 
    • TR-225 (NIH Number: 82-1781)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Bioassay of D & C Red No. 9 (CASRN 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 1000, 3000, M: 0, 1000, 2000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (832755)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (829033)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (794744)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (494246)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Salmonella  (358382)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (832755)  Completed 
    • Mice
    • Sister Chromatid  Positive