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Testing Status of 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 10768-A

 

CASRN: 15481-70-6

Formula: C7-H10-N2.2Cl-H

Synonyms/Common Names

  • 1,3-Benzenediamine, 2-methyl-, dihydrochloride (9CI)
  • 2,6-Diaminotoluene dihydrochloride

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50317)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50317)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 1000, M: 0, 10, 1000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50317)  Completed 
    • TR-200 (NIH Number: 80-1756)  (Peer Review Approval 02/15/1980A )
      Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CASRN 15481-70-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 250, 500, M: 0, 50, 100 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (051468)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Negative 
  • Chromosome Aberrations  (337746)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (774876)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (717361)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (256727)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (889785)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Positive 
  • Mouse Lymphoma  (612221)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (982821)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (051468)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Negative 
  • Sister Chromatid Exchanges  (337746)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98048)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice