Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of o-Nitrotoluene 10946-L

 

CASRN: 88-72-2

Formula: C7-H7-N-O2

Synonyms/Common Names

  • 1-Methyl-2-nitrobenzene (9CI)
  • 2-Nitrotoluene

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C62340)  Completed 
    • TOX-23 (NIH Number: 93-3346)  (Peer Review Approval 11/21/1991A )
      Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 1 week (Dosed-Feed)  (C62340C)  Completed 
    • TOX-44 (NIH Number: 96-3936)
      Comparative Toxicity and Carcinogenicity Studies of o-Nitrotoluene and o-Toluidine Hydrochloride Administered in Feed to Male F344/N Rats
    • Rats: F344/N
  • 13 weeks (Dosed-Feed)  (C62340)  Completed 
    • TOX-23 (NIH Number: 93-3346)
      Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, 10000 PPM/10 PER GROUP.
  • 26 weeks (Dosed-Feed)  (C62340C)  Completed 
    • TOX-44 (NIH Number: 96-3936)  (Tox Peer Review 08/00/1995A )
      Comparative Toxicity and Carcinogenicity Studies of o-Nitrotoluene and o-Toluidine Hydrochloride Administered in Feed to Male F344/N Rats
    • Rats: F344/N
    • Dose: MALE R: 0, 0 ALTERED MICROFLORA 20/GRP; 5000 PPM 60/GRP; 5000 PPM ALTERED MICROFLORA 40/GRP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C62340D)  Completed 
    • TR-504 (NIH Number: 02-4438)  (Peer Review Approval 05/03/2001A )
      Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0, 625, 1250, 2000, OR 5000 PPM FR: 0, 625, 1250, OR 2000 PPM M: 0, 1250, 2500, OR 5000 PPM; 60/SEX/DOSE.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0206)  Completed 
    • Male and Female Rats: Fischer 344; Male Mice: B6C3F1
    • Dose: 2, 200 mg/kg. 2, 200 mg/kg; male rat 200 mg/kg/day (14 day repeat).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (573604)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A25222)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A29734)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A80173)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (192331)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (692737)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative