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Testing Status of Isopropylated Phenol Phosphate 11037

 

CASRN: 68937-41-7

Synonyms/Common Names

  • Durad 100
  • Flame Retardant 1
  • IPP
  • Isopropylated phenol phosphate (3:1)
  • Isopropylated phenyl phosphate
  • Isopropylphenyl phosphate
  • Phenol isopropylated phosphate

Short-Term Toxicity

  • 5 days (Gavage)  (C10866B)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
  • 13 weeks (Dosed-Feed)  (C11037)  On Test 
    • Rats: Hsd:Sprague Dawley SD

Modified One-Generation

  • 14 days Dose Range Finding (Dosed-Feed)  (MOG10866)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 30000, 10000, 15000, or 30000 ppm.

Special Studies

  • C. elegans  (W10866)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMRepro: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400uM.

Genetic Toxicology

  • 3 months Micronucleus (Dosed-Feed) Selected (G10866B)  
    • 13-week subchronic study
    • Rats: Hsd:Sprague Dawley SD
  • Salmonella  (G10866)  Completed 
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Gavage)  (T10866)  Completed 
    • Rats: Harlan Sprague-Dawley