Testing Status of Codeine 11119-T
CASRN: 76-57-3
Related: CODEINE PHOSPHATE (CAS 52-28-8)
Formula: C18-H21-N-O3
Synonyms/Common Names
- Methylmorphine
- Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C61541A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C61541A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 390, 6250 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C61541C)
Completed
- TR-455 (NIH Number: 96-3360)
(Peer Review Approval 06/20/1995A )
Toxicology and Carcinogenesis Studies of Codeine (CASRN 76-57-3) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 400, 800, OR 1600 M: 0, 750, 1500, OR 3000 PPM; 60/GROUP.
- TR-455 (NIH Number: 96-3360)
(Peer Review Approval 06/20/1995A )
Special Studies
- Toxicokinetic Study (Gavage)
(K61541B)
Completed
- Rats: Fischer 344; Mice: B6C3F1
- Toxicokinetic Study (Gavage)
(K61541C)
Completed
- Male and Female Rats: Fischer 344
- Toxicokinetic Study (Gavage)
(K61541D)
Completed
- Male and Female Rats: Fischer 344
- Toxicokinetic Study (Gavage)
(K61541E)
Completed
- Male and Female Mice: B6C3F1
- Toxicokinetic Study (Gavage)
(K61541F)
Completed
- Male and Female Mice: B6C3F1
Organ Systems Toxicity
- 6 to 15 GD Conventional Teratology (Gavage)
(TER90057)
Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 37.5, 75, 150, 300 MG/KG/DAY.
- 5 to 13 GD Conventional Teratology (Gavage)
(TER90058)
Completed
- Female Hamsters: LVG (SYR)
- Hamsters Maternal Positive
- Hamsters Fetal Positive
- Dose: 0, 10, 50, 150 MG/KG/DAY.